Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 12/20 | 0.72 |
| ▸ | FEN1 | P39748 | 12/20 | 0.72 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.54 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.54 |
| ▸ | TDP2 | O95551 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15916977 | 0.84 | ALOX5AP (1.00) | ALOX5APFEN1 | |
| SCHEMBL26932401 | 0.82 | BRD4 (0.49) | ALOX5APFEN1GRIA1CACNG8TDP2 | |
| SCHEMBL24884440 | 0.81 | GRIA1 (0.69) | ALOX5APFEN1GRIA1CACNG8TDP2 | |
| SCHEMBL30191144 | 0.78 | TDP2 (0.74) | ALOX5APFEN1GRIA1CACNG8TDP2 | |
| SCHEMBL1899295 | 0.78 | TDP2 (0.74) | ALOX5APFEN1GRIA1CACNG8TDP2 | |
| SCHEMBL21089073 | 0.74 | ALOX5AP (0.64) | ALOX5APFEN1GRIA1CACNG8TDP2 | |
| SCHEMBL10712809 | 0.73 | GRIA1 (0.69) | ALOX5APFEN1GRIA1CACNG8TDP2 | |
| SCHEMBL1900635 | 0.72 | PDE3B (0.64) | ALOX5APFEN1GRIA1CACNG8TDP2 | |
| SCHEMBL21483771 | 0.71 | GRIA1 (0.66) | ALOX5APFEN1GRIA1CACNG8TDP2 | |
| SCHEMBL15932372 | 0.71 | ALOX5AP (1.00) | ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2951170-A2 | FLAP MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2015-12-09 | — | — | EP | disclosed |
| WO-2014121055-A2 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-07 | — | — | WO | disclosed |