Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 4/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21729380 | 0.92 | GPR84 (0.39) | GPR84FFAR1IMPDH2HTR2AHTR2C | |
| SCHEMBL399231 | 0.80 | HTR2A (0.47) | GPR84FFAR1IMPDH2HTR2AHTR2C | |
| SCHEMBL20048442 | 0.78 | GPR84 (0.71) | GPR84FFAR1HTR2AHTR2CHTR2B | |
| SCHEMBL5488035 | 0.76 | IMPDH2 (0.46) | GPR84FFAR1IMPDH2HTR2AHTR2C | |
| SCHEMBL396507 | 0.76 | IMPDH2 (0.46) | GPR84FFAR1IMPDH2HTR2AHTR2C | |
| SCHEMBL5851341 | 0.73 | GPR84 (0.62) | GPR84FFAR1HTR2AHTR2CHTR2B | |
| SCHEMBL14145831 | 0.71 | GPR84 (0.75) | GPR84FFAR1HTR2AHTR2CHTR2B | |
| SCHEMBL20226530 | 0.70 | PDE2A (0.35) | ALDH1A1TP53CYP3A4MEN1KMT2A | |
| SCHEMBL852664 | 0.70 | KDM4E (0.41) | CYP2C19ALDH1A1TP53CYP1A2CYP3A4 | |
| SCHEMBL29045649 | 0.70 | GPR84 (0.61) | GPR84FFAR1HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558446-B1 | NOVEL COMPOUNDS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH AMYLOID OR AMYLOID-LIKE PROTEINS | AC IMMUNE SA (CH) | 2019-06-12 | — | — | EP | disclosed |