Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 19/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 18/20 | 0.36 |
| ▸ | NNMT | P40261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24067669 | 0.75 | PRMT5 (0.34) | PRMT5WDR77NNMT | |
| SCHEMBL21129817 | 0.73 | PRMT5 (0.33) | PRMT5WDR77NNMT | |
| SCHEMBL25949485 | 0.73 | PRMT5 (0.39) | PRMT5WDR77 | |
| SCHEMBL22508810 | 0.72 | PRMT5 (0.41) | PRMT5WDR77 | |
| SCHEMBL25049137 | 0.71 | NNMT (0.36) | PRMT5WDR77NNMT | |
| SCHEMBL19344195 | 0.71 | PRMT5 (0.37) | PRMT5WDR77NNMT | |
| SCHEMBL24595470 | 0.71 | PRMT5 (0.35) | PRMT5WDR77NNMT | |
| SCHEMBL20049423 | 0.71 | PRMT5 (0.37) | PRMT5WDR77NNMT | |
| SCHEMBL24090740 | 0.70 | PRMT5 (0.40) | PRMT5WDR77NNMT | |
| SCHEMBL25949284 | 0.69 | PRMT5 (0.41) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019112719-A1 | HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | ANGEX PHARMACEUTICAL, INC. (US) | 2019-06-13 | — | — | WO | disclosed |