Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | BCHE | P06276 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | DRD1 | P21728 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21095124 | 0.90 | LMNA (0.75) | KCNH2LMNAKDM4EALDH1A1HSD17B10 | |
| Dimethylgrisabine SCHEMBL30735570 | 0.85 | LMNA (0.84) | KCNH2LMNAKDM4EALDH1A1HSD17B10 | |
| SCHEMBL29819356 | 0.81 | KCNH2 (0.81) | KCNH2LMNAKDM4EALDH1A1HSD17B10 | |
| SCHEMBL32690224 | 0.80 | KCNH2 (0.85) | KCNH2LMNAKDM4EALDH1A1HSD17B10 | |
| SCHEMBL21346112 | 0.79 | LMNA (0.93) | KCNH2LMNAKDM4EALDH1A1HSD17B10 | |
| Dauricine SCHEMBL22089144 | 0.79 | KCNH2 (1.00) | KCNH2LMNAKDM4EALDH1A1HSD17B10 | |
| Dauricine SCHEMBL2233953 | 0.79 | KCNH2 (1.00) | KCNH2LMNAKDM4EALDH1A1HSD17B10 | |
| Dauricine SCHEMBL29494084 | 0.79 | KCNH2 (1.00) | KCNH2LMNAKDM4EALDH1A1HSD17B10 | |
| Dauricine SCHEMBL28689430 | 0.79 | KCNH2 (1.00) | KCNH2LMNAKDM4EALDH1A1HSD17B10 | |
| Dauricine SCHEMBL29494083 | 0.79 | KCNH2 (1.00) | KCNH2LMNAKDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2805954-B1 | 7-SUBSTITUTED HANFANGICHIN B DERIVATIVE, AND PREPARATION METHOD AND USE THEREOF | HANGZHOU BENSHENG PHARMACEUTICAL CO LTD (CN) | 2019-06-19 | — | — | EP | disclosed |