Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | TSHR | P16473 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21085252 | 0.89 | ALDH1A1 (0.46) | NPSR1ALDH1A1TSHRNOTUMMEN1 | |
| SCHEMBL255037 | 0.85 | NOTUM (0.50) | NPSR1ALDH1A1TSHRHTTNOTUM | |
| SCHEMBL17776524 | 0.83 | NOTUM (0.49) | NPSR1ALDH1A1TSHRHTTNOTUM | |
| SCHEMBL21677078 | 0.82 | NOTUM (0.47) | NPSR1ALDH1A1TSHRHTTNOTUM | |
| SCHEMBL19163454 | 0.82 | NOTUM (0.47) | NPSR1ALDH1A1TSHRHTTNOTUM | |
| SCHEMBL9668715 | 0.82 | NOTUM (0.47) | NPSR1ALDH1A1TSHRHTTNOTUM | |
| SCHEMBL9315735 | 0.82 | NOTUM (0.51) | NPSR1ALDH1A1TSHRHTTNOTUM | |
| SCHEMBL7111926 | 0.81 | ALDH1A1 (0.47) | NPSR1ALDH1A1TSHRHTTNOTUM | |
| SCHEMBL18954412 | 0.81 | NOTUM (0.50) | NPSR1ALDH1A1TSHRHTTNOTUM | |
| SCHEMBL15445286 | 0.80 | NOTUM (0.45) | NPSR1ALDH1A1TSHRHTTNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3498708-B1 | DEUTERATED 3-(4,5-SUBSTITUTED PYRIMIDINAMINE) PHENYL DERIVATIVES AND APPLICATIONS THEREOF | NANJING CHUANGTE PHARMACEUTICAL TECH CO LTD (CN) | 2021-01-13 | — | — | EP | disclosed |
| EP-3498708-A1 | DEUTERATED 3-(4,5-SUBSTITUTED PYRIMIDINAMINE) PHENYL DERIVATIVES AND APPLICATIONS THEREOF | Nanjing Chuangte Pharmaceutical Technology Co., Ltd (CN) | 2019-06-19 | — | — | EP | disclosed |