Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CCND1 | P24385 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21095412 | 0.89 | NPSR1 (0.49) | ALDH1A1TSHRNPSR1MEN1KMT2A | |
| SCHEMBL1102007 | 0.84 | ALDH1A1 (0.48) | ALDH1A1TSHRNPSR1SLC6A2SLC6A4 | |
| SCHEMBL6262183 | 0.81 | SLC6A2 (0.52) | ALDH1A1TSHRNPSR1SLC6A2SLC6A4 | |
| SCHEMBL11852260 | 0.81 | GAA (0.47) | ALDH1A1TSHRNPSR1SLC6A2SLC6A4 | |
| SCHEMBL16600454 | 0.81 | ALDH1A1 (0.46) | ALDH1A1TSHRNPSR1SLC6A2SLC6A4 | |
| SCHEMBL14060360 | 0.81 | ALDH1A1 (0.46) | ALDH1A1TSHRNPSR1SLC6A2SLC6A4 | |
| SCHEMBL20957018 | 0.80 | SLC6A2 (0.46) | ALDH1A1TSHRNPSR1SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL31467512 | 0.79 | SLC6A2 (0.47) | ALDH1A1TSHRNPSR1SLC6A2SLC6A4 | |
| SCHEMBL24729037 | 0.78 | ALDH1A1 (0.47) | ALDH1A1TSHRNPSR1SLC6A2SLC6A4 | |
| SCHEMBL8216960 | 0.78 | ALDH1A1 (0.47) | ALDH1A1TSHRNPSR1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190167651-A1 | HETEROARYL SULFONAMIDES AND CCR2/CCR9 | CHEMOCENTRYX, INC. | 2019-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190167651-A1 | HETEROARYL SULFONAMIDES AND CCR2/CCR9 | CCR2, CCR9, CCR1 | ALDH1A1 2834/4885TSHR 1094/4885NPSR1 462/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.