SCHEMBL21095413

SCHEMBL21095413

CCc1[nH]c(COC)nc1C

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.38
HCAR2 Q8TDS4 1/20 0.38
CCNE1 P24864 1/20 0.35
CDK2 P24941 1/20 0.35
CACNA1H O95180 1/20 0.33
FASN P49327 1/20 0.31
L3MBTL1 Q9Y468 2/20 0.31
LMNA P02545 1/20 0.31
MEN1 O00255 1/20 0.31
PDE5A O76074 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP3A4 P08684 1/20 0.31
TSHR P16473 1/20 0.31
CYP2C19 P33261 1/20 0.31
BLM P54132 1/20 0.31
PDE1A P54750 1/20 0.31
PDE1B Q01064 1/20 0.31
KMT2A Q03164 1/20 0.31
PDE1C Q14123 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7451055 0.82 SMN1; SMN2 (0.37) ALDH1A1SMN1; SMN2HCAR2CCNE1CDK2
SCHEMBL6855320 0.81 ADORA1 (0.43) SMN1; SMN2L3MBTL1TP53
SCHEMBL20470648 0.77 SMN1; SMN2 (0.41) ALDH1A1SMN1; SMN2HCAR2CCNE1CDK2
SCHEMBL3696311 0.75 GLA (0.38) ALDH1A1L3MBTL1KMT2ATP53
SCHEMBL15554665 0.73 SMN1; SMN2 (0.39) ALDH1A1SMN1; SMN2HCAR2CCNE1CDK2
SCHEMBL18294954 0.71 SMN1; SMN2 (0.55) ALDH1A1SMN1; SMN2HCAR2CCNE1CDK2
SCHEMBL25047048 0.70 L3MBTL1 (0.44) ALDH1A1SMN1; SMN2L3MBTL1TP53
SCHEMBL3698711 0.69
SCHEMBL15204695 0.68 ALDH1A1 (0.34) ALDH1A1L3MBTL1
SCHEMBL21526048 0.68 SMN1; SMN2 (0.49) ALDH1A1SMN1; SMN2HCAR2CCNE1CDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3083583-B1 HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS AND COMBINATIONS THEREOF SAGIMET BIOSCIENCES INC (US) 2020-11-18 EP disclosed
EP-2870150-B1 HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS 3 V BIOSCIENCES INC (US) 2019-06-19 EP disclosed