Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A12 | P48065 | 3/20 | 0.39 |
| ▸ | SLC6A11 | P48066 | 3/20 | 0.39 |
| ▸ | SLC6A13 | Q9NSD5 | 3/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21095889 | 1.00 | SLC6A12 (0.39) | SLC6A12SLC6A11SLC6A13CHRM1CHRNB2 | |
| SCHEMBL21063808 | 0.90 | CHRNA7 (0.41) | SLC6A12SLC6A11SLC6A13CHRM1CHRNA4 | |
| SCHEMBL21063738 | 0.90 | CHRNA7 (0.41) | SLC6A12SLC6A11SLC6A13CHRM1CHRNA4 | |
| SCHEMBL4280104 | 0.90 | CHRNA7 (0.41) | SLC6A12SLC6A11SLC6A13CHRM1CHRNA4 | |
| Hydrochloric Acid SCHEMBL23406281 | 0.88 | SLC6A12 (0.42) | SLC6A12SLC6A11SLC6A13CHRM1CHRNA4 | |
| Hydrochloric Acid SCHEMBL2422058 | 0.88 | SLC6A12 (0.42) | SLC6A12SLC6A11SLC6A13CHRM1CHRNA4 | |
| SCHEMBL29271818 | 0.88 | CHRNA7 (0.40) | SLC6A12SLC6A11SLC6A13CHRM1CHRNA4 | |
| SCHEMBL9698974 | 0.82 | CHRNA7 (0.39) | CHRM1CHRNB2CHRNA4CHRNA7CHRM2 | |
| SCHEMBL2416972 | 0.77 | ALDH1A1 (0.38) | CHRM1CHRNB2CHRNA4CHRM2MEN1 | |
| SCHEMBL4762164 | 0.77 | ALDH1A1 (0.38) | CHRM1CHRNB2CHRNA4CHRM2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3724188-B1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | ARKUDA THERAPEUTICS (US) | 2023-06-07 | — | — | EP | disclosed |
| WO-2019118528-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | ARKUDA THERAPEUTICS (US) | 2019-06-20 | — | — | WO | disclosed |