Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.64 |
| ▸ | NPC1 | O15118 | 6/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 4/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | MGAM | O43451 | 3/20 | 0.38 |
| ▸ | SI | P14410 | 3/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13160177 | 0.79 | RAB9A (0.66) | RAB9AKDM4ENPC1SMN1; SMN2HPGD | |
| SCHEMBL23328879 | 0.79 | RAB9A (0.66) | RAB9AKDM4ENPC1SMN1; SMN2HPGD | |
| SCHEMBL10022384 | 0.78 | KDM4E (1.00) | RAB9AKDM4ENPC1SMN1; SMN2HPGD | |
| SCHEMBL16847023 | 0.74 | ALDH1A1 (0.52) | RAB9AKDM4ENPC1SMN1; SMN2NPSR1 | |
| SCHEMBL21095773 | 0.74 | RAB9A (0.58) | RAB9AKDM4ENPC1SMN1; SMN2HPGD | |
| SCHEMBL13020134 | 0.74 | S1PR1 (0.71) | S1PR1S1PR3 | |
| SCHEMBL1505214 | 0.73 | NR1H4 (0.62) | RAB9AKDM4ENPC1SMN1; SMN2HPGD | |
| SCHEMBL17184775 | 0.70 | KDM4E (0.46) | RAB9AKDM4ENPC1SMN1; SMN2HPGD | |
| SCHEMBL1505311 | 0.69 | RAB9A (0.53) | RAB9AKDM4ENPC1SMN1; SMN2HPGD | |
| SCHEMBL12925903 | 0.68 | RAB9A (0.51) | RAB9AKDM4ENPC1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3724188-B1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | ARKUDA THERAPEUTICS (US) | 2023-06-07 | — | — | EP | disclosed |
| WO-2019118528-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | ARKUDA THERAPEUTICS (US) | 2019-06-20 | — | — | WO | disclosed |