Flucarbril

Flucarbril

SCHEMBL2109672

Cn1c(=O)ccc2cc(C(F)(F)F)ccc21

nearest known ligand 0.57

Full drug profile on Sugi Atlas →

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
BRPF1 P55201 14/20 0.57
BRD4 O60885 4/20 0.50
BRD9 Q9H8M2 4/20 0.50
CA12 O43570 1/20 0.50
CA9 Q16790 1/20 0.50
KAT2B Q92831 1/20 0.50
BRD1 O95696 7/20 0.43
BRPF3 Q9ULD4 3/20 0.43
KIF11 P52732 1/20 0.42
KCNH2 Q12809 1/20 0.42
TRPV1 Q8NER1 1/20 0.39
ALOX5 P09917 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Flucarbril SCHEMBL30086956 1.00 BRPF1 (0.57) BRPF1BRD4BRD9CA12CA9
SCHEMBL31743109 0.88 BRPF1 (0.52) BRPF1BRD4BRD9CA12CA9
SCHEMBL762351 0.84 BRPF1 (0.59) BRPF1BRD4BRD9CA12CA9
SCHEMBL19495463 0.79 MAPK9 (0.45)
SCHEMBL28916372 0.77 BRPF1 (0.54) BRPF1BRD4BRD9CA12CA9
SCHEMBL9257087 0.77 BRPF1 (0.62) BRPF1BRD4BRD9CA12CA9
SCHEMBL422084 0.74 BRPF1 (0.65) BRPF1BRD4BRD9CA12CA9
SCHEMBL2172818 0.73 BRPF1 (0.62) BRPF1BRD4BRD9CA12CA9
SCHEMBL1771879 0.73 BRPF1 (0.62) BRPF1BRD4BRD9CA12CA9
SCHEMBL8556776 0.73 BRPF1 (0.62) BRPF1BRD4BRD9CA12CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 CN claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
US-20220047505-A1 Controlled Absorption Water-Soluble Pharmaceutically Active Organic Compound Formulation for Once-Daily Administration STI PHARMA, LLC (US) 2022-02-17 US disclosed
US-10463611-B2 Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration STI PHARMA, LLC (US) 2019-11-05 US disclosed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US disclosed
US-20140154313-A1 Controlled Absorption Water-Soluble Pharmaceutically Active Organic Compound Formulation for Once-Daily Administration STI PHARMA, LLC (US) 2014-06-05 US disclosed
EP-2717860-A1 CONTROLLED ABSORPTION WATER-SOLUBLE PHARMACEUTICALLY ACTIVE ORGANIC COMPOUND FORMULATION FOR ONCE-DAILY ADMINISTRATION STI Pharma, LLC (US) 2014-04-16 EP disclosed
WO-2012170676-A1 CONTROLLED ABSORPTION WATER-SOLUBLE PHARMACEUTICALLY ACTIVE ORGANIC COMPOUND FORMULATION FOR ONCE-DAILY ADMINISTRATION STI PHARMA, LLC (US) 2012-12-13 WO disclosed
US-8158152-B2 Preparing lyophilizates, especially those free of undesired extra components such as mono- or disaccharides; dosage forms of a wide variety of over 2000 drugs, such as rapidly dissolving tablets SCIDOSE LLC (US) 2012-04-17 US disclosed
US-7905852-B2 Skin-contacting-adhesive free dressing JENNINGS-SPRING BARBARA 2011-03-15 US disclosed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US disclosed
WO-2010024870-A1 SKIN-CONTACTING-ADHESIVE FREE DRESSING JENNINGS-SPRING BARBARA BROOKE (US) 2010-03-04 WO disclosed
US-20090005722-A1 Skin-contacting-adhesive free dressing JENNLNGS-SPRING BARBARA 2009-01-01 US disclosed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP disclosed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO disclosed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US disclosed