SCHEMBL21096985

SCHEMBL21096985

C=Cc1cccc([SiH2]C)c1

nearest known ligand 0.54

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.54
TDP1 Q9NUW8 1/20 0.54
ALDH1A1 P00352 3/20 0.42
TSHR P16473 1/20 0.42
HDAC8 Q9BY41 2/20 0.36
PTGS2 P35354 1/20 0.36
TRPA1 O75762 1/20 0.33
MAPT P10636 1/20 0.30
PKM P14618 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28216374 0.78 TP53 (0.48) TP53TDP1ALDH1A1TSHRHDAC8
SCHEMBL21881 0.75 TDP1 (0.67) TP53TDP1ALDH1A1TSHRHDAC8
SCHEMBL4156637 0.75 ACHE (0.35)
SCHEMBL10621574 0.75 TP53 (0.46) TP53TDP1ALDH1A1TSHRHDAC8
SCHEMBL23493483 0.75 TP53 (0.46) TP53TDP1ALDH1A1TSHRHDAC8
SCHEMBL29434594 0.74 TP53 (0.44) TP53TDP1ALDH1A1TSHRPTGS2
SCHEMBL23493451 0.74 TP53 (0.44) TP53TDP1ALDH1A1TSHRPTGS2
SCHEMBL29434665 0.74 TP53 (0.44) TP53TDP1ALDH1A1TSHRPTGS2
SCHEMBL23493404 0.74 TP53 (0.44) TP53TDP1ALDH1A1TSHRPTGS2
SCHEMBL23493419 0.74 TP53 (0.44) TP53TDP1ALDH1A1TSHRHDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110105495-B Rare earth styrene derivative/isoprene/butadiene ternary rubber and preparation method thereof 大连理工大学 2021-12-24 CN disclosed
US-10325773-B2 Conformal deposition of silicon carbide films NOVELLUS SYSTEMS, INC. (US) 2019-06-18 US disclosed