Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3716987 | 0.83 | MAPK1 (0.49) | MAPK1KDM4EL3MBTL1ATMNOTUM | |
| SCHEMBL21061893 | 0.82 | ALDH1A1 (0.46) | MAPK1KDM4EL3MBTL1ATMNOTUM | |
| SCHEMBL21061790 | 0.82 | KDM4E (0.46) | MAPK1KDM4EL3MBTL1ATMNOTUM | |
| SCHEMBL12143900 | 0.81 | MAPK1 (0.47) | MAPK1KDM4EL3MBTL1ATMNOTUM | |
| SCHEMBL21061759 | 0.80 | HSD17B10 (0.54) | MAPK1KDM4EL3MBTL1MAPTALDH1A1 | |
| SCHEMBL21061785 | 0.80 | MAPK1 (0.41) | MAPK1KDM4EL3MBTL1ATMNOTUM | |
| SCHEMBL21096510 | 0.80 | NOTUM (0.46) | MAPK1KDM4EL3MBTL1ATMNOTUM | |
| SCHEMBL21061842 | 0.80 | MAPK1 (0.41) | MAPK1KDM4EL3MBTL1ATMNOTUM | |
| SCHEMBL18358176 | 0.79 | MAPK1 (0.45) | MAPK1KDM4EL3MBTL1ATMNOTUM | |
| SCHEMBL23350346 | 0.78 | NOTUM (0.44) | MAPK1KDM4EL3MBTL1ATMNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019116256-A1 | FUSED PYRIDINES WHICH ACT AS INHIBITORS OF H-PGDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-06-20 | — | — | WO | disclosed |