Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 12/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 12/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | CYP21A2 | P08686 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21097301 | 1.00 | GRIA4 (0.36) | GRIA4JAK2NTRK1NR3C2PSEN1 | |
| SCHEMBL21097324 | 0.84 | NTRK1 (0.45) | JAK2NTRK1 | |
| SCHEMBL21097326 | 0.84 | NTRK1 (0.45) | JAK2NTRK1 | |
| SCHEMBL21097309 | 0.82 | TRPA1 (0.48) | NR3C2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21097310 | 0.82 | TRPA1 (0.48) | NR3C2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21097347 | 0.76 | JAK2 (0.35) | JAK2NTRK1 | |
| SCHEMBL21097348 | 0.76 | JAK2 (0.35) | JAK2NTRK1 | |
| SCHEMBL15017388 | 0.74 | NTRK1 (0.46) | JAK2NTRK1 | |
| SCHEMBL16293124 | 0.69 | NTRK1 (0.45) | JAK2NTRK1 | |
| SCHEMBL28129544 | 0.69 | NTRK1 (0.47) | JAK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10344031-B2 | Substituted pyrazolo[1,5-a] pyridine as tropomyosin receptor kinase (Trk) inhibitors | DR. REDDY'S LABORATORIES LTD. (IN) | 2019-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10344031-B2 | Substituted pyrazolo[1,5-a] pyridine as tropomyosin receptor kinase (Trk) inhibitors | MUSK, DMPK, PNCK | GRIA4 1897/4885JAK2 700/4885NTRK1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.