Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.48 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.32 |
| ▸ | TOP2A | P11388 | 1/20 | 0.32 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.31 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.30 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.30 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.30 |
| ▸ | AKT1 | P31749 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1235939 | 0.87 | TLR8 (0.48) | TLR8BRD9NPC1RAB9A | |
| SCHEMBL30006352 | 0.87 | TLR8 (0.48) | TLR8BRD9NPC1RAB9A | |
| SCHEMBL1238110 | 0.79 | TLR8 (0.55) | TLR8CYP17A1TLR7 | |
| SCHEMBL27175795 | 0.77 | TLR8 (0.39) | TLR8TOP2ATOP2BMEN1NPC1 | |
| SCHEMBL18041313 | 0.76 | TLR8 (0.67) | TLR8TLR7 | |
| SCHEMBL20442362 | 0.74 | TLR8 (0.41) | TLR8BRD9TOP2ATOP2BCYP17A1 | |
| SCHEMBL2333056 | 0.74 | TLR8 (0.51) | TLR8TLR7 | |
| SCHEMBL21912241 | 0.73 | TLR8 (0.72) | TLR8TLR7 | |
| SCHEMBL25688112 | 0.73 | TLR8 (0.69) | TLR8TLR7 | |
| SCHEMBL16592818 | 0.72 | TLR8 (0.41) | TLR8MEN1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019118884-A1 | ANTIBODY CONSTRUCT-DRUG CONJUGATE FOR THE TREATMENT OF HEPATITIS | SILVERBACK THERAPEUTICS, INC. (US) | 2019-06-20 | — | — | WO | disclosed |