Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.40 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.40 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1748004 | 0.79 | SMN1; SMN2 (0.63) | LCKNPC1RAB9ASMN1; SMN2HSD17B10 | |
| SCHEMBL20049226 | 0.79 | LMNA (0.46) | LCKNPC1RAB9ASMN1; SMN2HSD17B10 | |
| SCHEMBL20043370 | 0.78 | KMT2A (0.43) | LCKNPC1RAB9ASMN1; SMN2CHRNA7 | |
| SCHEMBL1033009 | 0.74 | LMNA (0.64) | LCKNPC1RAB9ACHRNA7HSD17B10 | |
| SCHEMBL2000313 | 0.73 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2KMT2ALRRK2 | |
| SCHEMBL1983363 | 0.72 | PIK3CA (0.64) | NPC1RAB9ASMN1; SMN2HSD17B10KMT2A | |
| SCHEMBL1095256 | 0.72 | SMN1; SMN2 (0.46) | NPC1RAB9ASMN1; SMN2HSD17B10KMT2A | |
| SCHEMBL1036069 | 0.72 | KDM4E (0.62) | NPC1RAB9ASMN1; SMN2HSD17B10KMT2A | |
| SCHEMBL1748094 | 0.71 | POLB (0.55) | RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL9305825 | 0.71 | NPC1 (0.72) | LCKNPC1RAB9ASMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019118571-A1 | ISOXAZOLE ANALOGS AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. (US) | 2019-06-20 | — | — | WO | disclosed |