Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5216018 | 0.79 | HRH3 (0.43) | MAPTPIK3CGKMT2ACXCR4SMN1; SMN2 | |
| SCHEMBL13631416 | 0.79 | SMN1; SMN2 (0.43) | KDM4EMAPTPIK3CGKMT2ACXCR4 | |
| SCHEMBL15703566 | 0.75 | PIK3CG (0.42) | MAPTPIK3CGKMT2ACXCR4SMN1; SMN2 | |
| SCHEMBL23023786 | 0.75 | PIK3CG (0.42) | MAPTPIK3CGKMT2ACXCR4SMN1; SMN2 | |
| SCHEMBL16509710 | 0.72 | SMN1; SMN2 (0.45) | KDM4EMAPTKMT2ACXCR4SMN1; SMN2 | |
| SCHEMBL5212793 | 0.71 | MEN1 (0.50) | KDM4EMAPTPIK3CGKMT2ASMN1; SMN2 | |
| SCHEMBL11218649 | 0.71 | SMN1; SMN2 (0.38) | KDM4EMAPTPIK3CGKMT2ACXCR4 | |
| SCHEMBL14078255 | 0.69 | RAB9A (0.58) | MAPTPIK3CGKMT2ASMN1; SMN2RAB9A | |
| SCHEMBL14018820 | 0.68 | MAPT (0.43) | KDM4EMAPTKMT2ASMN1; SMN2POLB | |
| SCHEMBL13061370 | 0.68 | HRH3 (0.67) | KDM4EMAPTKMT2ASMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019118313-A1 | IMIDAZO [1,2-C] QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES | MERCK SHARP & DOHME CORP. (US) | 2019-06-20 | — | — | WO | disclosed |