Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP8B1 | Q9UNU6 | 1/20 | 0.34 |
| ▸ | NR1D1 | P20393 | 2/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21137316 | 0.94 | MET (0.39) | METKCNH2GPR119PRKCQALDH1A1 | |
| SCHEMBL21099203 | 0.94 | MET (0.39) | METKCNH2GPR119PRKCQALDH1A1 | |
| SCHEMBL21099361 | 0.94 | MET (0.39) | METKCNH2GPR119PRKCQALDH1A1 | |
| SCHEMBL21099211 | 0.88 | SMARCA2 (0.37) | GPR119IDO1TDO2 | |
| SCHEMBL21050918 | 0.87 | ABL1 (0.36) | ALDH1A1CYP8B1 | |
| SCHEMBL21050822 | 0.87 | MET (0.39) | METKCNH2GPR119PRKCQALDH1A1 | |
| SCHEMBL21100021 | 0.87 | MET (0.39) | METKCNH2GPR119PRKCQALDH1A1 | |
| SCHEMBL21136775 | 0.85 | MET (0.47) | METKCNH2ALDH1A1LMNAMAPT | |
| SCHEMBL21099345 | 0.82 | MET (0.41) | METGPR119PRKCQALDH1A1LMNA | |
| SCHEMBL21050677 | 0.81 | ABL1 (0.36) | ALDH1A1CYP8B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190177338-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2019-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190177338-A1 | CHEMICAL COMPOUNDS | MKI67, CCNI, MCL1 | MET 467/4885KCNH2 4078/4885GPR119 945/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.