Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PGK1 | P00558 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CKS1B | P61024 | 1/20 | 0.37 |
| ▸ | SKP1 | P63208 | 1/20 | 0.37 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | CYP8B1 | Q9UNU6 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21136848 | 0.88 | MET (0.47) | METKCNH2ALDH1A1LMNAMAPT | |
| SCHEMBL21137056 | 0.86 | GPR119 (0.41) | METKCNH2ALDH1A1LMNAMAPT | |
| SCHEMBL21136722 | 0.85 | MAP4K4 (0.42) | METKCNH2MAPTMAPK8POLB | |
| SCHEMBL21099361 | 0.85 | MET (0.39) | METKCNH2ALDH1A1LMNAMAPT | |
| SCHEMBL21137316 | 0.85 | MET (0.39) | METKCNH2ALDH1A1LMNAMAPT | |
| SCHEMBL21100021 | 0.85 | MET (0.39) | METKCNH2ALDH1A1LMNAMAPT | |
| SCHEMBL21099607 | 0.85 | MET (0.39) | METKCNH2ALDH1A1LMNAMAPT | |
| SCHEMBL21099203 | 0.85 | MET (0.39) | METKCNH2ALDH1A1LMNAMAPT | |
| SCHEMBL21050822 | 0.85 | MET (0.39) | METKCNH2ALDH1A1LMNAMAPT | |
| SCHEMBL21136735 | 0.84 | KCNH2 (0.47) | METKCNH2ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019110751-A1 | TETRACYCLIC COMPOUNDS AS INHIBITORS OF G12C MUTANT RAS PROTEIN, FOR USE AS ANTI-CANCER AGENTS | ASTRAZENECA AB (SE) | 2019-06-13 | — | — | WO | disclosed |