Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCND3 | P30281 | 8/20 | 0.51 |
| ▸ | CDK6 | Q00534 | 8/20 | 0.51 |
| ▸ | CCNK | O75909 | 7/20 | 0.51 |
| ▸ | CDK9 | P50750 | 7/20 | 0.51 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | PRKCI | P41743 | 2/20 | 0.46 |
| ▸ | CDK4 | P11802 | 2/20 | 0.44 |
| ▸ | CCND1 | P24385 | 2/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.41 |
| ▸ | CDK2 | P24941 | 5/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21099810 | 0.89 | IRAK4 (0.46) | CCND3CDK6CCNKCDK9EGFR | |
| SCHEMBL19867209 | 0.84 | ALK (0.58) | CCND3CDK6CCNKCDK9EGFR | |
| SCHEMBL21099502 | 0.83 | ALK (0.59) | EGFRIRAK4CDK2ALKPTK2 | |
| SCHEMBL21099556 | 0.82 | IRAK4 (0.56) | CCND3CDK6CCNKCDK9EGFR | |
| SCHEMBL21100193 | 0.79 | IRAK4 (0.59) | EGFRIRAK4ALKJAK2LRRK2 | |
| SCHEMBL19867369 | 0.76 | ALK (0.60) | CCND3CDK6CCNKCDK9EGFR | |
| SCHEMBL21099501 | 0.76 | ALK (0.52) | EGFRALKPTK2IGF1RTNK2 | |
| SCHEMBL21099812 | 0.74 | CCND3 (0.54) | CCND3CDK6CCNKCDK9EGFR | |
| SCHEMBL21099605 | 0.73 | ALK (0.62) | EGFRALKPTK2IGF1R | |
| SCHEMBL19867213 | 0.73 | ALK (0.62) | CDK9EGFRCDK4IRAK4CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3498716-A1 | THIENOPYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND APPLICATIONS | Hongyun Biotech Co., Ltd. (CN) | 2019-06-19 | — | — | EP | disclosed |