Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NSD1 | Q96L73 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21091219 | 0.84 | ALDH1A1 (0.49) | ALDH1A1CYP3A4TDP1HSD17B10CYP1A2 | |
| SCHEMBL28795289 | 0.83 | CYP3A4 (0.60) | ALDH1A1CYP3A4TDP1HSD17B10CYP1A2 | |
| SCHEMBL29803040 | 0.83 | CYP3A4 (0.60) | ALDH1A1CYP3A4TDP1HSD17B10CYP1A2 | |
| SCHEMBL2664863 | 0.81 | HSD17B10 (0.64) | ALDH1A1CYP3A4TDP1HSD17B10CYP1A2 | |
| SCHEMBL9722840 | 0.81 | CYP3A4 (0.58) | ALDH1A1CYP3A4TDP1HSD17B10CYP1A2 | |
| SCHEMBL21395394 | 0.80 | CYP3A4 (0.57) | ALDH1A1CYP3A4TDP1HSD17B10CYP1A2 | |
| SCHEMBL21091722 | 0.80 | CYP3A4 (0.57) | ALDH1A1CYP3A4TDP1HSD17B10CYP1A2 | |
| SCHEMBL20319227 | 0.80 | CYP3A4 (0.57) | ALDH1A1CYP3A4TDP1HSD17B10CYP1A2 | |
| SCHEMBL21054913 | 0.80 | NSD1 (0.58) | ALDH1A1CYP3A4TDP1HSD17B10CYP1A2 | |
| SCHEMBL28213770 | 0.80 | CYP3A4 (0.57) | ALDH1A1CYP3A4TDP1HSD17B10CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230046569-A1 | NSD FAMILY INHIBITORS AND METHODS OF TREATMENT THEREWITH | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2023-02-16 | — | — | US | disclosed |
| US-11324729-B2 | NSD family inhibitors and methods of treatment therewith | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2022-05-10 | — | — | US | disclosed |
| US-20190183865-A1 | NSD FAMILY INHIBITORS AND METHODS OF TREATMENT THEREWITH | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2019-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230046569-A1 | NSD FAMILY INHIBITORS AND METHODS OF TREATMENT THEREWITH | NSD3, NSD2, NSD1 | ALDH1A1 3591/4885CYP3A4 3981/4885TDP1 1117/4885 |
| US-11324729-B2 | NSD family inhibitors and methods of treatment therewith | NSD3, NSD2, NSD1 | ALDH1A1 3591/4885CYP3A4 3981/4885TDP1 1117/4885 |
| US-20190183865-A1 | NSD FAMILY INHIBITORS AND METHODS OF TREATMENT THEREWITH | NSD3, NSD2, NSD1 | ALDH1A1 3591/4885CYP3A4 3981/4885TDP1 1117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.