Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDIA3 | P30101 | 3/20 | 0.62 |
| ▸ | PDIA6 | Q15084 | 3/20 | 0.62 |
| ▸ | PDIA4 | P13667 | 2/20 | 0.44 |
| ▸ | TXNDC5 | Q8NBS9 | 1/20 | 0.43 |
| ▸ | GBA1 | P04062 | 3/20 | 0.35 |
| ▸ | UGCG | Q16739 | 3/20 | 0.35 |
| ▸ | GBA2 | Q9HCG7 | 3/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | PREP | P48147 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 2/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | BRS3 | P32247 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21100884 | 1.00 | PDIA3 (0.62) | PDIA3PDIA6PDIA4TXNDC5GBA1 | |
| SCHEMBL22030635 | 0.91 | PDIA3 (0.64) | PDIA3PDIA6PDIA4TXNDC5GBA1 | |
| SCHEMBL25997799 | 0.91 | PDIA3 (0.64) | PDIA3PDIA6PDIA4TXNDC5GBA1 | |
| SCHEMBL21100891 | 0.91 | PDIA3 (0.64) | PDIA3PDIA6PDIA4TXNDC5GBA1 | |
| SCHEMBL21100892 | 0.91 | PDIA3 (0.64) | PDIA3PDIA6PDIA4TXNDC5GBA1 | |
| SCHEMBL21100885 | 0.87 | PDIA3 (0.64) | PDIA3PDIA6PDIA4TXNDC5 | |
| SCHEMBL21100881 | 0.87 | PDIA3 (0.64) | PDIA3PDIA6PDIA4TXNDC5 | |
| SCHEMBL21100893 | 0.83 | PDIA3 (0.56) | PDIA3PDIA6PDIA4TXNDC5MAOA | |
| SCHEMBL21064820 | 0.78 | PDIA3 (1.00) | PDIA3PDIA6PDIA4TXNDC5 | |
| SCHEMBL22030264 | 0.78 | PDIA3 (0.78) | PDIA3PDIA6PDIA4TXNDC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11731952-B2 | Indene derivatives and uses thereof | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2023-08-22 | — | — | US | disclosed |
| US-20200165182-A1 | INDENE DERIVATIVES AND USES THEREOF | Leukogene Therapeutics Incorporated | 2020-05-28 | — | — | US | disclosed |
| US-10329269-B2 | Indene derivatives and uses thereof | Leukogene Therapeutics Incorporated (US) | 2019-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200165182-A1 | INDENE DERIVATIVES AND USES THEREOF | CYP11B2, CYP1B1, CYP3A5 | PDIA3 736/4885PDIA6 1350/4885PDIA4 1280/4885 |
| US-11731952-B2 | Indene derivatives and uses thereof | CYP11B2, CYP1B1, CYP3A5 | PDIA3 736/4885PDIA6 1350/4885PDIA4 1280/4885 |
| US-10329269-B2 | Indene derivatives and uses thereof | CYP11B2, CYP1B1, CYP3A5 | PDIA3 736/4885PDIA6 1350/4885PDIA4 1280/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.