Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1D1 | P20393 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23924565 | 0.91 | NR1H2 (0.45) | JAK2JAK1NR1H2GPR119MEN1 | |
| SCHEMBL21101365 | 0.88 | NR1H2 (0.40) | NR1D1JAK2JAK1NR1H2GPR119 | |
| SCHEMBL24033522 | 0.82 | NR1H2 (0.44) | NR1D1JAK2JAK1NR1H2GPR119 | |
| SCHEMBL24033340 | 0.82 | NR1H2 (0.44) | NR1D1JAK2JAK1NR1H2GPR119 | |
| SCHEMBL21101363 | 0.81 | USP2 (0.40) | JAK2JAK1GPR119USP30MEN1 | |
| SCHEMBL1996182 | 0.80 | NR1H2 (0.48) | NR1D1JAK2JAK1NR1H2GPR119 | |
| SCHEMBL3568388 | 0.80 | NR1H2 (0.48) | NR1D1JAK2JAK1NR1H2GPR119 | |
| SCHEMBL3564630 | 0.80 | NR1H2 (0.48) | NR1D1JAK2JAK1NR1H2GPR119 | |
| SCHEMBL15411988 | 0.79 | RORC (0.48) | NR1D1JAK2JAK1GPR119KDM4E | |
| SCHEMBL15411990 | 0.79 | RORC (0.48) | NR1D1JAK2JAK1GPR119KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2688568-B1 | CYCLOPROPYLAMINES AS LSD1 INHIBITORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2019-06-19 | — | — | EP | disclosed |