Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | KDM1A | O60341 | 7/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.50 |
| ▸ | TLR2 | O60603 | 3/20 | 0.49 |
| ▸ | TLR1 | Q15399 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15541914 | 1.00 | SMN1; SMN2 (0.63) | SMN1; SMN2NPSR1KDM1ACNR1EPHX2 | |
| SCHEMBL23653279 | 1.00 | SMN1; SMN2 (0.63) | SMN1; SMN2NPSR1KDM1ACNR1EPHX2 | |
| SCHEMBL28949881 | 0.83 | SMN1; SMN2 (0.68) | SMN1; SMN2NPSR1KDM1ACNR1EPHX2 | |
| SCHEMBL19609160 | 0.82 | KDM1A (0.48) | SMN1; SMN2NPSR1KDM1AEPHX2MAOB | |
| SCHEMBL6153775 | 0.80 | SMN1; SMN2 (0.73) | SMN1; SMN2NPSR1KDM1ACNR1EPHX2 | |
| SCHEMBL7980208 | 0.80 | SMN1; SMN2 (0.73) | SMN1; SMN2NPSR1KDM1ACNR1EPHX2 | |
| SCHEMBL3457343 | 0.80 | SMN1; SMN2 (0.73) | SMN1; SMN2NPSR1KDM1ACNR1EPHX2 | |
| SCHEMBL6154005 | 0.80 | SMN1; SMN2 (0.73) | SMN1; SMN2NPSR1KDM1ACNR1EPHX2 | |
| SCHEMBL15541004 | 0.80 | PGR (0.48) | SMN1; SMN2NPSR1CNR1 | |
| SCHEMBL15716012 | 0.79 | KDM1A (0.44) | SMN1; SMN2NPSR1KDM1AEPHX2TLR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106488915-B | Cyclopropylamines as LSD1 inhibitors | 因赛特公司 | 2020-10-02 | — | — | CN | disclosed |
| EP-2688568-B1 | CYCLOPROPYLAMINES AS LSD1 INHIBITORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2019-06-19 | — | — | EP | disclosed |
| CN-108779096-A | A kind of fluorine-substituted cyclopropylamine class compound and preparation method thereof, pharmaceutical composition and purposes | 中国科学院上海药物研究所 | 2018-11-09 | — | — | CN | disclosed |