Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 2/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.60 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.60 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.60 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.60 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.60 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | KDM1A | O60341 | 5/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19725557 | 0.85 | KDM1A (0.67) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL12821459 | 0.83 | KDM1A (0.80) | HDAC6HDAC1HDAC8HDAC3HDAC7 | |
| SCHEMBL12965593 | 0.83 | KDM1A (0.80) | HDAC6HDAC1HDAC8HDAC3HDAC7 | |
| SCHEMBL21101256 | 0.83 | SIGMAR1 (0.52) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL21101175 | 0.78 | KDM1A (0.58) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL26229597 | 0.77 | KDM1A (0.75) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL21101194 | 0.77 | MCHR1 (0.56) | KDM1ADRD2MAOBHTR2ASLC6A4 | |
| SCHEMBL28169202 | 0.77 | CXCR4 (0.68) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL8315153 | 0.76 | HDAC3 (0.69) | CCR2HDAC6HDAC1HDAC8HDAC3 | |
| SCHEMBL21101005 | 0.75 | KDM1A (0.50) | CCR2HDAC6HDAC1HDAC8HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2688568-B1 | CYCLOPROPYLAMINES AS LSD1 INHIBITORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2019-06-19 | — | — | EP | disclosed |