Danazol

Danazol

SCHEMBL21107

C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ARPGR

The experimentally established mechanism targets of Danazol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PGR known ✓ P06401 3/20 1.00
AR known ✓ P10275 2/20 0.59
CYP3A4 P08684 8/20 1.00
LMNA P02545 6/20 1.00
TSHR P16473 5/20 1.00
CYP2C19 P33261 5/20 1.00
HIF1A Q16665 5/20 1.00
CYP2D6 P10635 4/20 1.00
CYP2C9 P11712 4/20 1.00
SHBG P04278 4/20 1.00
ESR1 P03372 4/20 1.00
CYP1A2 P05177 3/20 1.00
NR3C1 P04150 3/20 1.00
ALDH1A1 P00352 3/20 1.00
MAPT P10636 2/20 1.00
USP2 O75604 2/20 1.00
NR1I2 O75469 2/20 1.00
ABCB11 O95342 2/20 1.00
ADORA3 P0DMS8 2/20 1.00
ADRB3 P13945 2/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Danazol SCHEMBL14045163 1.00 CYP3A4 (1.00) CYP3A4LMNATSHRCYP2C19HIF1A
Danazol SCHEMBL5021653 1.00 CYP3A4 (1.00) CYP3A4LMNATSHRCYP2C19HIF1A
Danazol SCHEMBL5499397 1.00 CYP3A4 (1.00) CYP3A4LMNATSHRCYP2C19HIF1A
Danazol SCHEMBL13184574 1.00 CYP3A4 (1.00) CYP3A4LMNATSHRCYP2C19HIF1A
Danazol SCHEMBL7722243 1.00 CYP3A4 (1.00) CYP3A4LMNATSHRCYP2C19HIF1A
Danazol SCHEMBL23468175 1.00 CYP3A4 (1.00) CYP3A4LMNATSHRCYP2C19HIF1A
Danazol SCHEMBL5248054 0.99 CYP3A4 (0.98) CYP3A4LMNATSHRCYP2C19HIF1A
Danazol SCHEMBL27720831 0.96 CYP3A4 (0.93) CYP3A4LMNATSHRCYP2C19HIF1A
Danazol SCHEMBL4780325 0.93 LMNA (0.86) CYP3A4LMNATSHRCYP2C19HIF1A
Danazol SCHEMBL3146698 0.89 CYP3A4 (0.80) CYP3A4LMNATSHRCYP2C19HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 17594 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260139065-A1 TREATMENT OF AIHA WITH BAFF OR BAFF RECEPTOR INHIBITORY ANTIBODIES NOVARTIS AG (CH) 2026-05-21 US claimed
CN-122063219-A Method for simultaneously measuring 31 stimulant substances in complex matrix cosmetics 国家体育总局反兴奋剂中心(中国反兴奋剂中心) 2026-05-19 CN claimed
WO-2026099483-A1 A READY-TO-USE DRUG DELIVERY SYSTEM SEVER PHARMA SOLUTIONS (SE) 2026-05-15 WO claimed
US-20260108619-A1 CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS HANGZHOU DAC BIOTECH CO., LTD. (CN) 2026-04-23 US claimed
US-20260098088-A1 ANTI-HEMOJUVELIN (HJV) ANTIBODIES FOR TREATING MYELOFIBROSIS DISC MEDICINE, INC. (US) 2026-04-09 US claimed
US-12594237-B2 Mucoadhesive gel composition Viramal Limited (GB) 2026-04-07 US claimed
US-12576124-B2 Formulation of a conjugate of a tubulysin analog to a cell-binding molecule HANGZHOU DAC BIOTECH CO., LTD (CN) 2026-03-17 US claimed
EP-4706674-A2 PLASMA KALLIKREIN INHIBITORS AND USES THEREOF FOR TREATING HEREDITARY ANGIOEDEMA ATTACK Takeda Pharmaceutical Company Limited (JP) 2026-03-11 EP claimed
EP-4525938-B1 RADIOPHARMACEUTICAL COMPLEXES TARGETING PROSTATE-SPECIFIC MEMBRANE ANTIGEN AND ITS COMBINATIONS BAYER AG (DE) 2026-03-11 EP claimed
US-20260048013-A1 PHARMACEUTICAL FORMULATION WITH IMPROVED SOLUBILITY AND BIOAVAILABILITY CONSEJO SUPERIOR INVESTIGACION (ES) 2026-02-19 US claimed
EP-0330786-A1 Topical drug delivery systems containing danazol Igarashi, Masao (JP) 1989-09-06 EP claimed
US-4852579-A Photocharacterization and treatment of normal abnormal and ectopic endometrium KARL STORZ ENDOSCOPY GMBH AND COMPANY (DE) 1989-08-01 US claimed
US-4837212-A Treatment of hemolytic anemia with danazol UNIVERSITY OF MIAMI (US) 1989-06-06 US claimed
US-4835146-A Method of treating sickle cell anemia with danazol UNIVERSITY OF MIAMI (US) 1989-05-30 US claimed
EP-0310662-A1 PHOTOCHARACTERIZATION AND TREATMENT OF NORMAL, ABNORMAL AND ECTOPIC ENDOMETRIUM VANCAILLIE, Thierry Georges (US) 1989-04-12 EP claimed
US-4783337-A Osmotic system comprising plurality of members for dispensing drug ALZA CORPORATION (US) 1988-11-08 US claimed
WO-1988008273-A1 PHOTOCHARACTERIZATION AND TREATMENT OF NORMAL, ABNORMAL AND ECTOPIC ENDOMETRIUM VANCAILLIE THIERRY GEORGES (US) 1988-11-03 WO claimed
EP-0142309-A2 Method of preparing steroid compoundshaving a reduced particle size form STERWIN AG. (CH) 1985-05-22 EP claimed
US-4282218-A ANTIANDROGENS IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1981-08-04 US claimed
US-4055562-A Process for preparing pregn-20-yne compounds and novel product produced thereby STERLING DRUG INC. (US) 1977-10-25 US claimed