Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.77 |
| ▸ | FLT3 | P36888 | 11/20 | 0.77 |
| ▸ | FLT4 | P35916 | 6/20 | 0.77 |
| ▸ | KIT | P10721 | 3/20 | 0.77 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.75 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.75 |
| ▸ | AURKA | O14965 | 1/20 | 0.75 |
| ▸ | MET | P08581 | 1/20 | 0.75 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.75 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.70 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.64 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3267645 | 0.91 | ALK (0.73) | KDRFLT3FLT4KITAURKB | |
| SCHEMBL4460869 | 0.90 | KDR (0.68) | KDRFLT3FLT4KITAURKB | |
| SCHEMBL3717720 | 0.90 | KDR (0.68) | KDRFLT3FLT4KITAURKB | |
| SCHEMBL3718713 | 0.89 | KDR (0.73) | KDRFLT3FLT4KITAURKB | |
| SCHEMBL4461111 | 0.89 | KDR (0.73) | KDRFLT3FLT4KITAURKB | |
| SCHEMBL3273702 | 0.86 | FLT3 (0.76) | KDRFLT3FLT4KITAURKB | |
| SCHEMBL3268878 | 0.84 | KDR (0.76) | KDRFLT3FLT4KITAURKB | |
| SCHEMBL3268874 | 0.84 | ALK (0.83) | KDRFLT3FLT4KITAURKB | |
| SCHEMBL6585195 | 0.84 | KDR (0.67) | KDRFLT3FLT4KITAURKB | |
| SCHEMBL6587955 | 0.84 | ALK (0.83) | KDRFLT3FLT4KITAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158656-B2 | 2-indolinone derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors | SHENZHEN CHIPSCREEN BIOSCIENCES LTD. (CN) | 2012-04-17 | — | — | US | disclosed |
| EP-2029580-B1 | NOVEL INDOL-PYRROL DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE AND INFLAMMATORY DISEASES | SCHEBO BIOTECH AG (DE) | 2010-06-16 | — | — | EP | disclosed |
| US-20100035251-A1 | BioMarkers for the Progression of Alzheimer's Disease | HE YUNSHENG | 2010-02-11 | — | — | US | disclosed |
| US-20090298886-A1 | 2-INDOLINONE DERIVATIVES AS MULTI-TARGET PROTEIN KINASE INHIBITORS AND HISTONE DEACETYLASE INHIBITORS | CHIPSCREEN BIOSCIENCES, LTD. (CN) | 2009-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298886-A1 | 2-INDOLINONE DERIVATIVES AS MULTI-TARGET PROTEIN KINASE INHIBITORS AND HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC2, HDAC3 | KDR 2274/4885FLT3 1894/4885FLT4 3618/4885 |
| US-20100035251-A1 | BioMarkers for the Progression of Alzheimer's Disease | LRRK2, PSEN2, CLK2 | KDR 1446/4885FLT3 3804/4885FLT4 3601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.