Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tamibarotene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB known ✓ | P10826 | 17/20 | 0.67 |
| ▸ | RARA known ✓ | P10276 | 15/20 | 0.67 |
| ▸ | RARG | P13631 | 17/20 | 0.67 |
| ▸ | CYP26A1 | O43174 | 5/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | PGR | P06401 | 1/20 | 0.67 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.67 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.67 |
| ▸ | BLVRB | P30043 | 1/20 | 0.67 |
| ▸ | RXRA | P19793 | 7/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.66 |
| ▸ | GMNN | O75496 | 1/20 | 0.66 |
| ▸ | USP2 | O75604 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Temarotene SCHEMBL980221 | 0.85 | RARG (0.72) | RARBRARGRARACYP26A1CYP3A4 | |
| Tamibarotene SCHEMBL36207 | 0.82 | RARB (1.00) | RARBRARGRARACYP26A1CYP3A4 | |
| Tamibarotene SCHEMBL29373818 | 0.82 | RARB (1.00) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL2307487 | 0.81 | RARB (1.00) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL345071 | 0.81 | RARB (1.00) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL29836848 | 0.81 | RARB (1.00) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL177444 | 0.81 | RARB (1.00) | RARBRARGRARACYP26A1CYP3A4 | |
| Tamibarotene SCHEMBL21055743 | 0.81 | RARB (0.97) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL12646806 | 0.81 | RARG (0.65) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL12590205 | 0.81 | RARG (0.65) | RARBRARGRARACYP26A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3506914-A1 | NOVEL ACTIVE IMMUNOMODULATORY AGENT AND COMPOSITION CONTAINING SAME | Universite Clermont Auvergne (FR) | 2019-07-10 | — | — | EP | disclosed |