Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 4/20 | 0.54 |
| ▸ | TOP1 | P11387 | 4/20 | 0.54 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.53 |
| ▸ | CYCS | P99999 | 3/20 | 0.51 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5706254 | 0.97 | TERT (0.54) | TERTTOP1ABCG2CYCSENPP2 | |
| Hydrochloric Acid SCHEMBL31122235 | 0.97 | TERT (0.54) | TERTTOP1ABCG2CYCSENPP2 | |
| SCHEMBL949511 | 0.97 | TERT (0.57) | TERTTOP1ABCG2CYCSENPP2 | |
| SCHEMBL29414382 | 0.97 | TERT (0.57) | TERTTOP1ABCG2CYCSENPP2 | |
| SCHEMBL2338257 | 0.95 | TERT (0.55) | TERTTOP1ABCG2CYCSENPP2 | |
| SCHEMBL22265228 | 0.95 | TERT (0.55) | TERTTOP1ABCG2CYCSENPP2 | |
| SCHEMBL20856304 | 0.95 | TERT (0.59) | TERTTOP1ABCG2CYCSENPP2 | |
| Hydrochloric Acid SCHEMBL15768782 | 0.95 | TERT (0.55) | TERTTOP1ABCG2CYCSENPP2 | |
| SCHEMBL8430292 | 0.95 | TERT (0.55) | TERTTOP1ABCG2CYCSENPP2 | |
| SCHEMBL30539978 | 0.95 | TERT (0.55) | TERTTOP1ABCG2CYCSENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11204445-B2 | Ophthalmic lens comprising an encapsulated light-absorbing additive | ESSILOR INTERNATIONAL (FR) | 2021-12-21 | — | — | US | disclosed |
| US-20190212473-A1 | Ophthalmic Lens Comprising an Encapsulated Light-Absorbing Additive | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2019-07-11 | — | — | US | disclosed |