SCHEMBL21112928

SCHEMBL21112928

Cc1c(Oc2ccccc2)cccc1C(=O)OC[C@H]1O[C@@H](OCC[Si](C)(C)C)[C@H](O)[C@@H](O)[C@@H]1O

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TYMP P19971 1/20 0.41
XDH P47989 1/20 0.41
ALDH1A1 P00352 1/20 0.39
TSHR P16473 1/20 0.39
SLC5A1 P13866 2/20 0.39
SLC5A2 P31639 2/20 0.39
MAOB P27338 1/20 0.38
TDP1 Q9NUW8 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
CYP19A1 P11511 1/20 0.35
PRKCA P17252 1/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
KDM4E B2RXH2 1/20 0.34
SLC28A3 Q9HAS3 1/20 0.34
SYNJ2 O15056 3/20 0.34
DGAT1 O75907 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21149298 0.84 XDH (0.42) TYMPXDHSLC5A1SLC5A2MAOB
SCHEMBL20873307 0.80 XDH (0.57) TYMPXDHALDH1A1SLC5A1SLC5A2
SCHEMBL9313559 0.80 MAOB (0.51) TYMPXDHALDH1A1MAOBTDP1
SCHEMBL9313546 0.80 MAOB (0.51) TYMPXDHALDH1A1MAOBTDP1
SCHEMBL23488256 0.76 MAOB (0.41) TYMPXDHSLC5A1SLC5A2MAOB
SCHEMBL21149592 0.76 XDH (0.50) TYMPXDHALDH1A1SLC5A1SLC5A2
SCHEMBL21112926 0.76 TSHR (0.38) TYMPALDH1A1TSHRSLC5A1SLC5A2
SCHEMBL21112990 0.75 XDH (0.46) TYMPXDHSLC5A2TDP1CYP19A1
SCHEMBL23488265 0.74 MAOB (0.48) TYMPXDHSLC5A1SLC5A2MAOB
SCHEMBL23488599 0.74 KMT2A (0.41) TYMPXDHMAOBSMN1; SMN2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11090364-B2 Conjugates of a pharmaceutical agent and a moiety capable of binding to a glucose sensing protein SANOFI (FR) 2021-08-17 US disclosed
US-20190209656-A1 CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN SANOFI (FR) 2019-07-11 US disclosed
CN-109562185-A Novel conjugates of agents and moieties capable of binding to glucose-sensing proteins 赛诺菲 2019-04-02 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11090364-B2 Conjugates of a pharmaceutical agent and a moiety capable of binding to a glucose sensing protein GPR119, SLC2A8, SLC2A4 TYMP 1768/4885XDH 2871/4885ALDH1A1 1514/4885
US-20190209656-A1 CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN GPR119, SLC2A8, SLC2A4 TYMP 1768/4885XDH 2871/4885ALDH1A1 1514/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.