Sugi Predict

Sugi Predict / Compounds / SCHEMBL21113246

SCHEMBL21113246

SCHEMBL21113246

CCOC(=O)c1cc2cc(-c3cc(C)cc(C)c3)cn2c(C(C)=O)c1C

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ BAZ2B Q9UIF8 1/20 0.38
▸ BAZ2A Q9UIF9 1/20 0.38
▸ GAA P10253 6/20 0.36
▸ KDM4E B2RXH2 5/20 0.36
▸ ALDH1A1 P00352 5/20 0.36
▸ HPGD P15428 3/20 0.36
▸ HSD17B10 Q99714 2/20 0.36
▸ NPC1 O15118 3/20 0.36
▸ POLB P06746 1/20 0.36
▸ TSHR P16473 2/20 0.35
▸ GLA P06280 3/20 0.34
▸ KMT2A Q03164 2/20 0.34
▸ CNR2 P34972 1/20 0.34
▸ CA12 O43570 2/20 0.33
▸ CA1 P00915 2/20 0.33
▸ CA2 P00918 2/20 0.33
▸ CA7 P43166 2/20 0.33
▸ CA9 Q16790 2/20 0.33
▸ CA14 Q9ULX7 2/20 0.33
▸ LMNA P02545 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21156562 0.87 HPGD (0.37) BAZ2BBAZ2AGAAKDM4EALDH1A1
SCHEMBL21113224 0.87 ALDH1A1 (0.44) GAAKDM4EALDH1A1HPGDHSD17B10
SCHEMBL19964980 0.85 EED (0.43) KDM4EALDH1A1HPGDHSD17B10NPC1
SCHEMBL21113459 0.85 ALDH1A1 (0.37) BAZ2BBAZ2AGAAKDM4EALDH1A1
SCHEMBL19964897 0.85 CASP1 (0.45) KDM4EALDH1A1HPGDHSD17B10TSHR
SCHEMBL21113050 0.84 ALDH1A1 (0.41) GAAKDM4EALDH1A1HPGDHSD17B10
SCHEMBL21113232 0.83 PIK3CD (0.38) BAZ2BBAZ2AGAAKDM4EALDH1A1
SCHEMBL19964838 0.82 ERN1 (0.39) BAZ2BBAZ2AGAAKDM4EALDH1A1
SCHEMBL21157356 0.82 MAPT (0.44) GAAKDM4EALDH1A1HPGDHSD17B10
SCHEMBL21113062 0.81 ALDH1A1 (0.46) KDM4EALDH1A1HPGDHSD17B10ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109790160-B Pyrido five-membered aromatic ring compound, preparation method and application thereof 上海海和药物研究开发股份有限公司 2022-11-15 — — CN disclosed
US-10968215-B2 Pyrido five-element aromatic ring compound, preparation method therefor and use thereof SHANGHAI HAIHE PHARMACEUTICAL CO., LTD. (CN) 2021-04-06 — — US disclosed
EP-3524602-A1 PYRIDO FIVE-ELEMENT AROMATIC RING COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF Shanghai Haihe Pharmaceutical Co., Ltd. (CN) 2019-08-14 — — EP disclosed
US-20190211010-A1 PYRIDO FIVE-ELEMENT AROMATIC RING COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF HAIHE BIOPHARMA CO. LTD. (CN) 2019-07-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10968215-B2 Pyrido five-element aromatic ring compound, preparation method therefor and use thereof EZH2, IKZF2, SUZ12 BAZ2B 15/4885BAZ2A 38/4885GAA 4565/4885
US-20190211010-A1 PYRIDO FIVE-ELEMENT AROMATIC RING COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF EZH2, IKZF2, SUZ12 BAZ2B 15/4885BAZ2A 38/4885GAA 4565/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.