Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19974226 | 0.85 | ESR1 (0.34) | PDK2KMT2AESR1ESR2 | |
| SCHEMBL21110617 | 0.85 | PDK2 (0.40) | PDK2CYP1A2CYP2C19KMT2A | |
| SCHEMBL19980421 | 0.81 | CYP1A2 (0.41) | CYP1A2KMT2A | |
| SCHEMBL21113542 | 0.80 | CYP11B1 (0.32) | PDK2 | |
| SCHEMBL19980423 | 0.77 | ALDH1A1 (0.39) | PDK2CYP1A2CYP2C19KMT2AESR1 | |
| SCHEMBL19567023 | 0.77 | ALDH1A1 (0.39) | PDK2CYP1A2CYP2C19KMT2AESR1 | |
| SCHEMBL30322773 | 0.76 | KMT2A (0.41) | PDK2CYP1A2CYP2C19KMT2AESR1 | |
| SCHEMBL19009208 | 0.76 | KMT2A (0.41) | PDK2CYP1A2CYP2C19KMT2AESR1 | |
| SCHEMBL29739834 | 0.76 | CRHBP (0.36) | PDK2 | |
| SCHEMBL28767222 | 0.76 | CRHBP (0.36) | PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11447464-B2 | Compounds with spirobifluorene-structures | MERCK PATENT GMBH (DE) | 2022-09-20 | — | — | US | disclosed |
| US-20190194164-A1 | COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES | MERCK PATENT GMBH (DE) | 2019-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11447464-B2 | Compounds with spirobifluorene-structures | SLCO1B3, SLCO4C1, SLCO1B1 | PDK2 835/4885CYP1A2 787/4885CYP2C19 844/4885 |
| US-20190194164-A1 | COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES | SLCO1B3, SLCO4C1, SLCO1B1 | PDK2 835/4885CYP1A2 787/4885CYP2C19 844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.