Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.43 |
| ▸ | ICMT | O60725 | 3/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16629671 | 0.91 | CYP19A1 (0.47) | CYP19A1THRBADAM17ICMTHDAC6 | |
| SCHEMBL18014736 | 0.89 | CYP19A1 (0.45) | CYP19A1THRBADAM17ICMTHDAC6 | |
| SCHEMBL17968715 | 0.74 | PSEN1 (0.69) | — | |
| SCHEMBL21116049 | 0.70 | PDE4A (0.44) | ICMT | |
| SCHEMBL12517362 | 0.65 | CYP19A1 (0.59) | CYP19A1HDAC2HDAC3HDAC8SRD5A2 | |
| SCHEMBL21115994 | 0.65 | HTR1D (0.49) | — | |
| SCHEMBL9732645 | 0.64 | PLA2G2A (0.61) | ICMTHDAC6HDAC1HDAC2PLA2G2A | |
| SCHEMBL25960519 | 0.64 | CYP19A1 (0.57) | CYP19A1 | |
| SCHEMBL13802401 | 0.64 | PPARD (0.69) | ICMTPLA2G2A | |
| SCHEMBL9732261 | 0.63 | ICMT (0.56) | ADAM17ICMTPLA2G2AEGFRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3052495-B1 | NOVEL BICYCLIC PYRIDINONES AS GAMMA-SECRETASE MODULATORS | PFIZER (US) | 2019-06-26 | — | — | EP | disclosed |