Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.60 |
| ▸ | AR | P10275 | 5/20 | 0.47 |
| ▸ | USP7 | Q93009 | 1/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | CCNC | P24863 | 4/20 | 0.43 |
| ▸ | CDK8 | P49336 | 4/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18015720 | 0.87 | TRPA1 (0.61) | TRPA1ARUSP7CREBBPAPP | |
| SCHEMBL18014698 | 0.84 | TRPA1 (0.61) | TRPA1ARUSP7CREBBPAPP | |
| SCHEMBL21116102 | 0.84 | TRPA1 (0.57) | TRPA1ARUSP7CREBBPAPP | |
| SCHEMBL30549500 | 0.78 | TRPA1 (0.64) | TRPA1ARUSP7CREBBPAPP | |
| Hydrochloric Acid SCHEMBL30549506 | 0.77 | TRPA1 (0.63) | TRPA1ARUSP7CREBBPAPP | |
| SCHEMBL23638931 | 0.76 | TRPA1 (0.60) | TRPA1ARUSP7CREBBPAPP | |
| SCHEMBL31378486 | 0.74 | TRPA1 (0.59) | TRPA1ARUSP7CREBBPBRD4 | |
| SCHEMBL13106087 | 0.74 | BRD4 (0.54) | TRPA1ARBRD4TGFBR1 | |
| SCHEMBL21464284 | 0.73 | TRPA1 (0.58) | TRPA1ARUSP7CREBBPAPP | |
| SCHEMBL16459575 | 0.72 | TRPA1 (0.56) | TRPA1ARUSP7CREBBPAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3052495-B1 | NOVEL BICYCLIC PYRIDINONES AS GAMMA-SECRETASE MODULATORS | PFIZER (US) | 2019-06-26 | — | — | EP | disclosed |