Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.69 |
| ▸ | KDM1A | O60341 | 7/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | PIP4K2A | P48426 | 2/20 | 0.35 |
| ▸ | PIP4K2B | P78356 | 2/20 | 0.35 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3421761 | 0.88 | CYP3A4 (0.63) | CYP3A4KDM1AMAOAMAOBNR3C2 | |
| SCHEMBL2112242 | 0.86 | CYP3A4 (0.52) | CYP3A4KDM1AMAOAMAOBNR3C2 | |
| SCHEMBL726323 | 0.84 | CYP3A4 (0.64) | CYP3A4KDM1ANR3C2PDPK1BRD4 | |
| SCHEMBL3477314 | 0.83 | CYP3A4 (0.49) | CYP3A4KDM1AMAOAMAOBNR3C2 | |
| SCHEMBL2111363 | 0.82 | CYP3A4 (1.00) | CYP3A4KDM1AMAOAMAOBNR3C2 | |
| SCHEMBL2112475 | 0.82 | CYP3A4 (1.00) | CYP3A4KDM1AMAOAMAOBNR3C2 | |
| SCHEMBL725581 | 0.82 | CYP3A4 (1.00) | CYP3A4KDM1AMAOAMAOBNR3C2 | |
| SCHEMBL1543239 | 0.79 | CYP3A4 (0.68) | CYP3A4NR3C2PIP4K2APIP4K2BPIP4K2C | |
| SCHEMBL1543237 | 0.79 | CYP3A4 (0.68) | CYP3A4NR3C2PIP4K2APIP4K2BPIP4K2C | |
| SCHEMBL1542619 | 0.78 | CYP3A4 (0.67) | CYP3A4LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158803-B2 | Heterocyclic antiviral compounds | ROCHE PALO ALTO LLC (US) | 2012-04-17 | — | — | US | claimed |
| US-20100272677-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | LEE EUN KYUNG | 2010-10-28 | — | — | US | claimed |
| US-8158803-B2 | Heterocyclic antiviral compounds | ROCHE PALO ALTO LLC (US) | 2012-04-17 | — | — | US | disclosed |
| US-20100272677-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | LEE EUN KYUNG | 2010-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100272677-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | POLR2A, EIF2AK2, RRM2B | CYP3A4 417/4885KDM1A 1567/4885MAOA 733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.