Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18015849 | 0.87 | MTNR1A (0.45) | TP53MAPTSMN1; SMN2MTNR1BMTNR1A | |
| SCHEMBL25037452 | 0.85 | PON1 (0.51) | TP53MAPTSMN1; SMN2MTNR1BMTNR1A | |
| SCHEMBL18014739 | 0.84 | TP53 (0.41) | TP53MAPTSMN1; SMN2MTNR1BPPARD | |
| SCHEMBL21116466 | 0.84 | TP53 (0.46) | TP53MAPTSMN1; SMN2MTNR1BMTNR1A | |
| SCHEMBL16619764 | 0.83 | TP53 (0.43) | TP53MAPTSMN1; SMN2MTNR1BPPARD | |
| SCHEMBL17107455 | 0.83 | MAOB (0.44) | TP53MAPTSMN1; SMN2MTNR1BPPARD | |
| SCHEMBL17324189 | 0.80 | MTNR1A (0.40) | TP53MAPTSMN1; SMN2MTNR1BPPARD | |
| SCHEMBL16629667 | 0.78 | PON1 (0.58) | MAPTSMN1; SMN2 | |
| SCHEMBL4446704 | 0.77 | KIF11 (0.42) | TP53MAPTSMN1; SMN2EPHX2MAOB | |
| SCHEMBL13462293 | 0.77 | PTPN1 (0.50) | TP53MAPTSMN1; SMN2MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3052495-B1 | NOVEL BICYCLIC PYRIDINONES AS GAMMA-SECRETASE MODULATORS | PFIZER (US) | 2019-06-26 | — | — | EP | disclosed |