SCHEMBL21117175

SCHEMBL21117175

c1cnc2[nH]c(-c3ccc4ccoc4n3)cc2c1

nearest known ligand 0.48

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ RIPK1 Q13546 17/20 0.48
▸ CCNB2 O95067 1/20 0.44
▸ CDK1 P06493 1/20 0.44
▸ CCNB1 P14635 1/20 0.44
▸ CCNB3 Q8WWL7 1/20 0.44
▸ CLK2 P49760 2/20 0.44
▸ CLK3 P49761 2/20 0.44
▸ DYRK1A Q13627 2/20 0.44
▸ CCNE1 P24864 1/20 0.43
▸ CDK2 P24941 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20618201 0.84 GSK3B (0.40) RIPK1CCNB2CDK1CCNB1CCNB3
SCHEMBL24985762 0.77 CCNE1 (0.38) RIPK1CCNB2CDK1CCNB1CCNB3
SCHEMBL21755111 0.77 RIPK1 (0.53) RIPK1CCNB2CDK1CCNB1CCNB3
SCHEMBL24987967 0.75 CCNE1 (0.38) RIPK1CCNB2CDK1CCNB1CCNB3
SCHEMBL31704117 0.72 CCNB2 (0.65) RIPK1CCNB2CDK1CCNB1CCNB3
SCHEMBL14838870 0.72 CCNB2 (0.65) RIPK1CCNB2CDK1CCNB1CCNB3
SCHEMBL20622229 0.71 GSK3B (0.36) RIPK1CCNB2CDK1CCNB1CCNB3
SCHEMBL23389649 0.71 RIPK1 (0.52) RIPK1CCNB2CDK1CCNB1CCNB3
SCHEMBL29796712 0.71 RIPK1 (0.52) RIPK1CCNB2CDK1CCNB1CCNB3
SCHEMBL3672721 0.71 RIPK1 (0.54) RIPK1CCNB2CDK1CCNB1CCNB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10881666-B2 Combination pharmaceutical agents as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2021-01-05 — — US disclosed
US-20190192535-A1 COMBINATION PHARMACEUTICAL AGENTS AS RSV INHIBITORS ENANTA PHARMACEUTICALS, INC. 2019-06-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10881666-B2 Combination pharmaceutical agents as RSV inhibitors SERPINB1, FURIN, HIF1AN RIPK1 2027/4885CCNB2 2238/4885CDK1 1453/4885
US-20190192535-A1 COMBINATION PHARMACEUTICAL AGENTS AS RSV INHIBITORS SERPINB1, FURIN, HIF1AN RIPK1 2027/4885CCNB2 2238/4885CDK1 1453/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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