Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | AR | P10275 | 6/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | RXRA | P19793 | 9/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 9/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 9/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19004282 | 0.86 | IDO1 (0.51) | IDO1RXRAGRIN1GRIN2B | |
| SCHEMBL21326537 | 0.86 | IDO1 (0.40) | IDO1PIK3CA | |
| Hydrochloric Acid SCHEMBL20584769 | 0.85 | IDO1 (0.51) | IDO1RXRAGRIN1GRIN2B | |
| SCHEMBL21393543 | 0.85 | IDO1 (0.40) | IDO1RXRAGRIN1GRIN2B | |
| Hydrochloric Acid SCHEMBL29694899 | 0.85 | IDO1 (0.51) | IDO1RXRAGRIN1GRIN2B | |
| SCHEMBL21393614 | 0.84 | CYP1A2 (0.41) | IDO1 | |
| SCHEMBL21118309 | 0.83 | IDO1 (0.37) | IDO1ARRXRAGRIN1GRIN2B | |
| SCHEMBL30449560 | 0.82 | IDO1 (0.41) | IDO1ARPIK3CA | |
| SCHEMBL20198943 | 0.82 | IDO1 (0.41) | IDO1ARPIK3CA | |
| SCHEMBL21118120 | 0.81 | IDO1 (0.51) | IDO1RXRAGRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11078168-B2 | Substituted N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | Phenex Discovery Verwaltungs-GmbH (DE) | 2021-08-03 | — | — | US | disclosed |
| US-20190292160-A1 | SUBSTITUTED N-HYDROXYAMIDINOHETEROCYCLES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | Phenex Discovery Verwaltungs-GmbH (DE) | 2019-09-26 | — | — | US | disclosed |
| US-20190169140-A1 | IDO1 INHIBITOR AND PREPARATION METHOD AND APPLICATION THEREOF | SHANDONG LUYE PHARMACEUTICAL CO., LTD. (CN) | 2019-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11078168-B2 | Substituted N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | IDO1, IDO2, INMT | IDO1 1/4885AR 2332/4885PIK3CA 4048/4885 |
| US-20190169140-A1 | IDO1 INHIBITOR AND PREPARATION METHOD AND APPLICATION THEREOF | IDO1, IDO2, INMT | IDO1 1/4885AR 2627/4885PIK3CA 4004/4885 |
| US-20190292160-A1 | SUBSTITUTED N-HYDROXYAMIDINOHETEROCYCLES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | IDO1, IDO2, INMT | IDO1 1/4885AR 2332/4885PIK3CA 4048/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.