⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL191160 | 0.75 | — | — | |
| SCHEMBL20061328 | 0.72 | — | — | |
| SCHEMBL2113347 | 0.72 | — | — | |
| SCHEMBL3393860 | 0.71 | ADORA2A (0.38) | — | |
| SCHEMBL16461044 | 0.70 | LMNA (0.40) | — | |
| SCHEMBL6851914 | 0.69 | SMN1; SMN2 (0.37) | — | |
| SCHEMBL23053284 | 0.68 | TDP1 (0.35) | — | |
| SCHEMBL12495771 | 0.66 | ADORA2A (0.40) | — | |
| SCHEMBL24309838 | 0.66 | DPP4 (0.33) | — | |
| SCHEMBL9287299 | 0.65 | KDM4E (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158638-B2 | Pyrazolopyrimidine derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-04-17 | — | — | US | disclosed |
| US-8158638-B2 | Pyrazolopyrimidine derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-04-17 | — | — | US | disclosed |
| US-8158638-B2 | Pyrazolopyrimidine derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-04-17 | — | — | US | disclosed |
| EP-2065388-B1 | PYRAZOLOPYRIMIDINE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2011-09-07 | — | — | EP | disclosed |
| US-20100113410-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-05-06 | — | — | US | disclosed |
| US-20100113410-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-05-06 | — | — | US | disclosed |
| US-20100113410-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-05-06 | — | — | US | disclosed |
| EP-2065388-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2009-06-03 | — | — | EP | disclosed |