Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | APEX1 | P27695 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | EDNRA | P25101 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3009213 | 0.86 | CYP1A2 (0.50) | CYP1A2MCL1GPR35POLBGAA | |
| SCHEMBL1801577 | 0.75 | ALDH1A1 (0.47) | CYP1A2POLBGAAMAPTHSD17B10 | |
| SCHEMBL15182540 | 0.75 | CYP1A2 (0.67) | CYP1A2MCL1GPR35POLBGAA | |
| SCHEMBL15182532 | 0.75 | CYP1A2 (0.67) | CYP1A2MCL1GPR35GAAHSD17B10 | |
| SCHEMBL11843818 | 0.73 | POLB (0.57) | CYP1A2POLBGAAMAPTHSD17B10 | |
| SCHEMBL1356879 | 0.73 | CYP1A2 (0.55) | CYP1A2MCL1GPR35GAAHSD17B10 | |
| SCHEMBL16506662 | 0.73 | CYP1A2 (0.56) | CYP1A2MCL1GPR35POLBGAA | |
| SCHEMBL6796580 | 0.71 | POLB (0.39) | CYP1A2POLBGAAMAPTHSD17B10 | |
| SCHEMBL10650682 | 0.71 | POLB (0.39) | CYP1A2POLBGAAMAPTHSD17B10 | |
| SCHEMBL2805600 | 0.68 | POLB (0.57) | CYP1A2POLBGAAMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10711027-B2 | DNA polymerase beta inhibitors | THE JOHNS HOPKINS UNIVERSITY (US) | 2020-07-14 | — | — | US | disclosed |
| US-20190202853-A1 | DNA POLYMERASE BETA INHIBITORS | THE JOHNS HOPKINS UNIVERSITY | 2019-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10711027-B2 | DNA polymerase beta inhibitors | POLB, POLH, POLN | CYP1A2 2326/4885MCL1 1259/4885GPR35 4750/4885 |
| US-20190202853-A1 | DNA POLYMERASE BETA INHIBITORS | POLB, POLH, POLN | CYP1A2 2326/4885MCL1 1259/4885GPR35 4750/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.