Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | AGXT | P21549 | 1/20 | 0.32 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8195868 | 0.89 | HSP90AA1 (0.39) | ALDH1A1L3MBTL1HSD17B10LMNANOTUM | |
| SCHEMBL2112911 | 0.86 | AGXT (0.45) | ALDH1A1AGXTPOLBHSP90AA1HSP90AB1 | |
| SCHEMBL3393935 | 0.79 | AGXT (0.40) | ALDH1A1HSD17B10LMNAELANECYP1A2 | |
| SCHEMBL3392712 | 0.75 | CA2 (0.38) | ALDH1A1HSD17B10LMNAELANECYP1A2 | |
| SCHEMBL3395441 | 0.75 | AGXT (0.37) | ALDH1A1L3MBTL1HSD17B10LMNAELANE | |
| SCHEMBL3393653 | 0.75 | AGBL2 (0.39) | ALDH1A1HSD17B10LMNAELANEAGBL2 | |
| SCHEMBL2110182 | 0.74 | AGXT (0.36) | ALDH1A1HSD17B10LMNAELANECYP1A2 | |
| SCHEMBL7952261 | 0.74 | AGXT (0.62) | ALDH1A1HSD17B10CYP1A2CYP2C19AGXT | |
| SCHEMBL23856652 | 0.73 | GAA (0.35) | ALDH1A1L3MBTL1LMNANOTUMCYP1A2 | |
| SCHEMBL2111401 | 0.73 | AGXT (0.45) | ALDH1A1HSD17B10NOTUMCYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158638-B2 | Pyrazolopyrimidine derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-04-17 | — | — | US | disclosed |
| US-8158638-B2 | Pyrazolopyrimidine derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-04-17 | — | — | US | disclosed |
| US-8158638-B2 | Pyrazolopyrimidine derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-04-17 | — | — | US | disclosed |
| EP-2065388-B1 | PYRAZOLOPYRIMIDINE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2011-09-07 | — | — | EP | disclosed |
| US-20100113410-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-05-06 | — | — | US | disclosed |
| US-20100113410-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-05-06 | — | — | US | disclosed |
| US-20100113410-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-05-06 | — | — | US | disclosed |
| EP-2065388-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2009-06-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113410-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE | HSP90AB1, HSP90B1, HSP90AA1 | ALDH1A1 1077/4885L3MBTL1 3887/4885HSD17B10 1721/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.