Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 3/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.41 |
| ▸ | PLAU | P00749 | 2/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.41 |
| ▸ | KLK1 | P06870 | 1/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.40 |
| ▸ | HTR3B | O95264 | 2/20 | 0.40 |
| ▸ | HTR3A | P46098 | 2/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21119570 | 0.78 | NPSR1 (0.41) | PLAUSMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL9547587 | 0.77 | ESR1 (0.49) | F2PRSS1PLAUPLGKLKB1 | |
| SCHEMBL651823 | 0.74 | ESR1 (0.42) | F2PRSS1PLAUPLGKLKB1 | |
| SCHEMBL8325081 | 0.74 | ESR1 (0.42) | F2PRSS1PLAUPLGKLKB1 | |
| SCHEMBL14385153 | 0.74 | PLAU (0.45) | PLAUESR1ESR2CES2CES1 | |
| SCHEMBL27605169 | 0.70 | ALDH1A1 (0.44) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL21119566 | 0.70 | GRIN2D (0.39) | PRSS1MEN1ALDH1A1KMT2A | |
| SCHEMBL21120016 | 0.70 | AKR1C3 (0.36) | — | |
| SCHEMBL21119519 | 0.69 | NOS3 (0.47) | SMN1; SMN2MEN1ALDH1A1KMT2AKDM4E | |
| SCHEMBL9547516 | 0.69 | NPSR1 (0.54) | ESR1ESR2CES2CES1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3250565-B1 | TETRAZOLONES AS CARBOXYLIC ACID BIOISOSTERES | RIGEL PHARMACEUTICALS INC (US) | 2019-07-03 | — | — | EP | disclosed |