Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 16/20 | 0.67 |
| ▸ | CA1 | P00915 | 15/20 | 0.67 |
| ▸ | CA2 | P00918 | 15/20 | 0.67 |
| ▸ | CA12 | O43570 | 6/20 | 0.64 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.60 |
| ▸ | CA7 | P43166 | 2/20 | 0.59 |
| ▸ | DNASE1L3 | Q13609 | 1/20 | 0.53 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.53 |
| ▸ | ELF3 | P78545 | 1/20 | 0.53 |
| ▸ | MED23 | Q9ULK4 | 1/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12060571 | 0.93 | CA9 (0.69) | CA9CA1CA2CA12USP2 | |
| SCHEMBL12231957 | 0.88 | CA9 (0.72) | CA9CA1CA2CA12USP2 | |
| SCHEMBL15828111 | 0.88 | CA9 (0.83) | CA9CA1CA2CA12USP2 | |
| SCHEMBL18470198 | 0.88 | CA9 (0.72) | CA9CA1CA2CA12USP2 | |
| SCHEMBL23762521 | 0.87 | CA9 (0.66) | CA9CA1CA2CA12USP2 | |
| SCHEMBL23205535 | 0.86 | DNASE1L3 (0.63) | CA9CA1CA2CA12USP2 | |
| SCHEMBL13097493 | 0.86 | CA9 (0.75) | CA9CA1CA2CA12USP2 | |
| SCHEMBL19954964 | 0.86 | CA9 (0.72) | CA9CA1CA2CA12USP2 | |
| SCHEMBL12060447 | 0.86 | CA9 (0.75) | CA9CA1CA2CA12USP2 | |
| SCHEMBL2234764 | 0.86 | CA9 (0.83) | CA9CA1CA2CA12USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190202862-A1 | STAPLED AND STITCHED POLYPEPTIDES AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2019-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190202862-A1 | STAPLED AND STITCHED POLYPEPTIDES AND USES THEREOF | VIP, NGLY1, IAPP | CA9 1811/4885CA1 1006/4885CA2 3765/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.