Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | ADCY5 | O95622 | 3/20 | 0.39 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | NNMT | P40261 | 8/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21130182 | 0.89 | PIP4K2A (0.40) | SLC22A12ADCY5PIP4K2APRMT5WDR77 | |
| SCHEMBL25047944 | 0.86 | PIP4K2A (0.44) | SLC22A12ADCY5PIP4K2APRMT5WDR77 | |
| SCHEMBL21129938 | 0.85 | PIP4K2A (0.38) | SLC22A12ADCY5PIP4K2APRMT5WDR77 | |
| SCHEMBL21129819 | 0.84 | PIP4K2A (0.40) | SLC22A12ADCY5PIP4K2APRMT5WDR77 | |
| SCHEMBL30372589 | 0.83 | SLC22A12 (0.39) | SLC22A12PIP4K2APRMT5WDR77ACACB | |
| SCHEMBL29247142 | 0.83 | SLC22A12 (0.39) | SLC22A12PIP4K2APRMT5WDR77ACACB | |
| SCHEMBL29247145 | 0.83 | SLC22A12 (0.39) | SLC22A12PIP4K2APRMT5WDR77ACACB | |
| SCHEMBL16967987 | 0.82 | PIP4K2A (0.49) | SLC22A12PIP4K2APRMT5WDR77ACACB | |
| SCHEMBL25047477 | 0.82 | PIP4K2A (0.39) | ADCY5PIP4K2APRMT5WDR77NNMT | |
| SCHEMBL29247562 | 0.82 | NNMT (0.41) | SLC22A12PRMT5WDR77ACACBNNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3724190-B1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | LUPIN LTD (IN) | 2022-07-06 | — | — | EP | disclosed |
| WO-2019116302-A1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | LUPIN LIMITED (IN) | 2019-06-20 | — | — | WO | disclosed |