Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21130075 | 0.87 | MKNK2 (0.33) | MKNK2PRMT5WDR77MKNK1 | |
| SCHEMBL21130294 | 0.81 | — | — | |
| SCHEMBL21130003 | 0.77 | PRMT5 (0.35) | MKNK2PRMT5WDR77MKNK1 | |
| SCHEMBL21130002 | 0.76 | PRMT5 (0.39) | PRMT5WDR77 | |
| SCHEMBL21130158 | 0.76 | PRMT5 (0.39) | PRMT5WDR77 | |
| SCHEMBL21130285 | 0.75 | PRMT5 (0.32) | PRMT5WDR77 | |
| SCHEMBL21130283 | 0.73 | PRMT5 (0.34) | PRMT5WDR77 | |
| SCHEMBL21130161 | 0.73 | PRMT5 (0.43) | PRMT5WDR77 | |
| SCHEMBL2241217 | 0.73 | MKNK2 (0.41) | MKNK2PRMT5WDR77MKNK1 | |
| SCHEMBL5356546 | 0.70 | AURKA (0.43) | MKNK2PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3724190-B1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | LUPIN LTD (IN) | 2022-07-06 | — | — | EP | disclosed |
| WO-2019116302-A1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | LUPIN LIMITED (IN) | 2019-06-20 | — | — | WO | disclosed |