Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.69 |
| ▸ | DRD2 | P14416 | 4/20 | 0.67 |
| ▸ | DRD3 | P35462 | 4/20 | 0.67 |
| ▸ | DRD5 | P21918 | 2/20 | 0.65 |
| ▸ | HTR7 | P34969 | 5/20 | 0.65 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4938916 | 0.99 | SIGMAR1 (0.67) | SIGMAR1DRD2DRD3DRD5HTR7 | |
| SCHEMBL4687501 | 0.99 | SIGMAR1 (0.67) | SIGMAR1DRD2DRD3DRD5HTR7 | |
| Hydrochloric Acid SCHEMBL4929355 | 0.98 | SIGMAR1 (0.66) | SIGMAR1DRD2DRD3DRD5HTR7 | |
| Hypochlorous Acid SCHEMBL4929365 | 0.96 | SIGMAR1 (0.65) | SIGMAR1DRD2DRD3DRD5HTR7 | |
| SCHEMBL2114093 | 0.96 | SIGMAR1 (0.67) | SIGMAR1DRD2DRD3DRD5HTR7 | |
| SCHEMBL2111769 | 0.91 | SIGMAR1 (0.67) | SIGMAR1DRD2DRD3DRD5HTR7 | |
| SCHEMBL10366635 | 0.87 | DRD2 (0.63) | SIGMAR1DRD2DRD3DRD5HTR7 | |
| SCHEMBL3209296 | 0.86 | SIGMAR1 (0.63) | SIGMAR1DRD2DRD3DRD5HTR7 | |
| SCHEMBL11465528 | 0.86 | SIGMAR1 (0.76) | SIGMAR1DRD2DRD3HTR7ADRA1A | |
| SCHEMBL7486480 | 0.85 | SIGMAR1 (0.71) | SIGMAR1DRD2DRD3DRD5HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158809-B2 | Podophyllotoxin derivatives | SUTTER WEST BAY HOSPITALS (US) | 2012-04-17 | — | — | US | disclosed |
| US-20090298870-A1 | PODOPHYLLOTOXIN DERIVATIVES | Sutter West Bay Hospitals, dba California Pacific Medical Center and Catholic Healthcare West | 2009-12-03 | — | — | US | disclosed |
| CN-1511159-A | Nitrogen-based camptothecin derivatives | ����������̫ƽ��ҽѧ���� | 2004-07-07 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298870-A1 | PODOPHYLLOTOXIN DERIVATIVES | APEH, DAGLA, DPY30 | SIGMAR1 2960/4885DRD2 1471/4885DRD3 2147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.