Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.54 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.54 |
| ▸ | AR | P10275 | 9/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26613562 | 0.85 | PTGS2 (0.48) | ARPTGS2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21130590 | 0.81 | PDCD1 (0.53) | CD274PDCD1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29986356 | 0.79 | AR (0.59) | ARPTGS2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29986008 | 0.78 | AR (0.57) | ARPTGS2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL26740722 | 0.76 | NPC1 (0.57) | ARPTGS2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9641658 | 0.76 | AR (0.55) | ARPTGS2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21130430 | 0.75 | CD274 (0.53) | CD274PDCD1NPC1RAB9AMEN1 | |
| SCHEMBL16245269 | 0.74 | PDCD1 (0.76) | CD274PDCD1MEN1KMT2AS1PR1 | |
| SCHEMBL240495 | 0.73 | AR (0.55) | ARPTGS2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4788772 | 0.73 | AR (0.64) | ARPTGS2NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109689640-B | Compounds useful as immunomodulators | 百时美施贵宝公司 | 2022-01-04 | — | — | CN | disclosed |
| EP-3481815-B1 | 1,3-DIHYDROXY-PHENYL DERIVATIVES USEFUL AS IMMUNOMODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2021-09-29 | — | — | EP | disclosed |
| US-10590105-B2 | 1,3-dihydroxy-phenyl derivatives useful as immunomodulators | BRISTOL-MEYERS SQUIBB COMPANY (US) | 2020-03-17 | — | — | US | disclosed |
| US-20190185450-A1 | 1,3-DIHYDROXY-PHENYL DERIVATIVES USEFUL AS IMMUNOMODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2019-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190185450-A1 | 1,3-DIHYDROXY-PHENYL DERIVATIVES USEFUL AS IMMUNOMODULATORS | CD74, CD2, HAVCR2 | CD274 30/4885PDCD1 46/4885AR 2370/4885 |
| US-10590105-B2 | 1,3-dihydroxy-phenyl derivatives useful as immunomodulators | CD74, CD2, HAVCR2 | CD274 30/4885PDCD1 46/4885AR 2370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.