Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 5/20 | 0.53 |
| ▸ | PDCD1 | Q15116 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21130590 | 0.77 | PDCD1 (0.53) | CD274PDCD1NPC1S1PR1S1PR3 | |
| SCHEMBL3127751 | 0.76 | NPC1 (0.57) | NPC1S1PR1CYP1A2CYP2A6RAB9A | |
| SCHEMBL11066304 | 0.75 | PDCD1 (0.59) | CD274PDCD1NPC1S1PR1S1PR3 | |
| SCHEMBL28271036 | 0.75 | NPC1 (0.74) | NPC1CYP1A2CYP2A6RAB9AL3MBTL1 | |
| SCHEMBL21130425 | 0.75 | CD274 (0.54) | CD274PDCD1NPC1S1PR1S1PR3 | |
| SCHEMBL21130363 | 0.74 | PDCD1 (0.58) | CD274PDCD1S1PR1S1PR3CYP1A2 | |
| SCHEMBL807820 | 0.74 | NPC1 (0.62) | NPC1CYP1A2CYP2A6RAB9AL3MBTL1 | |
| SCHEMBL731645 | 0.74 | NPC1 (0.62) | NPC1CYP1A2CYP2A6RAB9AL3MBTL1 | |
| SCHEMBL16245269 | 0.73 | PDCD1 (0.76) | CD274PDCD1S1PR1S1PR3MEN1 | |
| SCHEMBL11065624 | 0.73 | PDCD1 (0.51) | CD274PDCD1NPC1S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109689640-B | Compounds useful as immunomodulators | 百时美施贵宝公司 | 2022-01-04 | — | — | CN | disclosed |
| EP-3481815-B1 | 1,3-DIHYDROXY-PHENYL DERIVATIVES USEFUL AS IMMUNOMODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2021-09-29 | — | — | EP | disclosed |
| US-10590105-B2 | 1,3-dihydroxy-phenyl derivatives useful as immunomodulators | BRISTOL-MEYERS SQUIBB COMPANY (US) | 2020-03-17 | — | — | US | disclosed |
| US-20190185450-A1 | 1,3-DIHYDROXY-PHENYL DERIVATIVES USEFUL AS IMMUNOMODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2019-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190185450-A1 | 1,3-DIHYDROXY-PHENYL DERIVATIVES USEFUL AS IMMUNOMODULATORS | CD74, CD2, HAVCR2 | CD274 30/4885PDCD1 46/4885NPC1 1063/4885 |
| US-10590105-B2 | 1,3-dihydroxy-phenyl derivatives useful as immunomodulators | CD74, CD2, HAVCR2 | CD274 30/4885PDCD1 46/4885NPC1 1063/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.