Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 6/20 | 0.75 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | ICMT | O60725 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25058915 | 0.93 | GPR84 (0.65) | GPR84IDO1ICMTHTR7CSNK2A1 | |
| SCHEMBL16454430 | 0.87 | GPR84 (0.71) | GPR84HTR7MTNR1AKMT2AHTR1A | |
| SCHEMBL17833262 | 0.85 | GPR84 (0.53) | GPR84CSNK2A1MEN1LMNACYP1A2 | |
| SCHEMBL24358682 | 0.85 | GPR84 (0.71) | GPR84IDO1HTR2BMTNR1AKMT2A | |
| SCHEMBL15264840 | 0.83 | GPR84 (0.65) | GPR84IDO1ICMTHTR7CSNK2A1 | |
| SCHEMBL16451189 | 0.82 | GPR84 (0.69) | GPR84IDO1HTR7CSNK2A1CYP1A2 | |
| SCHEMBL2535076 | 0.81 | GPR84 (0.73) | GPR84HTR7CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL15265531 | 0.81 | GPR84 (0.67) | GPR84HTR7CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL1305644 | 0.81 | GPR84 (0.67) | GPR84HTR7CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL1250301 | 0.81 | GPR84 (0.67) | GPR84HTR7CYP1A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2828256-B1 | CHEMICAL PROCESS FOR PREPARING SPIROINDOLONES AND INTERMEDIATES THEREOF | NOVARTIS AG (CH) | 2019-07-03 | — | — | EP | disclosed |
| CN-1105988-A | 1-amino-ethylindole-derivatives | HOFFMANN LA ROCHE (CH) | 1995-08-02 | — | — | CN | disclosed |