Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 20/20 | 0.79 |
| ▸ | TLR8 | Q9NR97 | 16/20 | 0.79 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30583332 | 1.00 | TLR7 (0.79) | TLR7TLR8NUDT1 | |
| SCHEMBL17190818 | 0.93 | TLR7 (0.69) | TLR7TLR8NUDT1 | |
| SCHEMBL3867690 | 0.92 | TLR7 (0.74) | TLR7TLR8NUDT1 | |
| SCHEMBL3863966 | 0.91 | TLR7 (0.76) | TLR7TLR8NUDT1 | |
| SCHEMBL1486698 | 0.90 | TLR7 (0.81) | TLR7TLR8NUDT1 | |
| SCHEMBL3865574 | 0.90 | TLR7 (0.63) | TLR7TLR8NUDT1 | |
| SCHEMBL3865767 | 0.89 | TLR7 (0.80) | TLR7TLR8NUDT1 | |
| SCHEMBL3862179 | 0.89 | TLR7 (0.68) | TLR7TLR8NUDT1 | |
| SCHEMBL6723995 | 0.88 | TLR7 (1.00) | TLR7TLR8NUDT1 | |
| SCHEMBL25927911 | 0.88 | TLR7 (0.79) | TLR7TLR8NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3134402-B1 | 4-AMINO-IMIDAZOQUINOLINE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2020-05-06 | — | — | EP | disclosed |
| EP-3134402-A1 | 4-AMINO-IMIDAZOQUINOLINE COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2017-03-01 | — | — | EP | disclosed |
| US-9447097-B2 | 4-amino-imidazoquinoline compounds | HOFFMANN-LA ROCHE INC. (US) | 2016-09-20 | — | — | US | disclosed |
| US-20160222010-A1 | 4-AMINO-IMIDAZOQUINOLINE COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2016-08-04 | — | — | US | disclosed |
| US-9334268-B2 | 4-amino-imidazoquinoline compounds | HOFFMAN-LA ROCHE INC. (US) | 2016-05-10 | — | — | US | disclosed |
| WO-2015162075-A1 | 4-AMINO-IMIDAZOQUINOLINE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-10-29 | — | — | WO | disclosed |
| US-20150299194-A1 | 4-AMINO-IMIDAZOQUINOLINE COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2015-10-22 | — | — | US | disclosed |
| US-8846710-B2 | Method of preferentially inducing the biosynthesis of interferon | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2014-09-30 | — | — | US | disclosed |
| US-8658666-B2 | Substituted imidazoquinolines and imidazonaphthyridines | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2014-02-25 | — | — | US | disclosed |
| US-8158794-B2 | Hydroxyalkyl substituted imidazoquinoline compounds and methods | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2012-04-17 | — | — | US | disclosed |
| EP-1845988-A2 | SUBSTITUTED IMIDAZOQUINOLINES AND IMIDAZONAPHTHYRIDINES | 3M Innovative Properties Company (US) | 2007-10-24 | — | — | EP | disclosed |
| US-20070213356-A1 | Nitrogen-Containing Heterocyclyl Substituted Imidazoquinolines and Imidazonaphthyridines | 3M INNOVATIVE PROPERTIES COMPANY | 2007-09-13 | — | — | US | disclosed |
| WO-2006091394-A2 | SUBSTITUTED IMIDAZOQUINOLINES AND IMIDAZONAPHTHYRIDINES | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2006-08-31 | — | — | WO | disclosed |
| WO-2006091647-A2 | METHOD OF PREFERENTIALLY INDUCING THE BIOSYNTHESIS OF INTERFERON | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2006-08-31 | — | — | WO | disclosed |
| US-7091214-B2 | Aryl substituted Imidazoquinolines | 3M INNOVATIVE PROPERTIES CO. (US) | 2006-08-15 | — | — | US | disclosed |
| US-20060111387-A1 | ARYL SUBSTITUTED IMIDAZOQUINOLINES | 3M INNOVATIVE PROPERTIES COMPANY | 2006-05-25 | — | — | US | disclosed |
| WO-2005123080-A2 | NITROGEN-CONTAINING HETEROCYCLYL SUBSTITUTED IMIDAZOQUINOLINES AND IMIDAZONAPHTHYRIDINES | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |
| EP-1590348-A1 | ARYL / HETARYL SUBSTITUTED IMIDAZOQUINOLINES | 3M Innovative Properties Company (US) | 2005-11-02 | — | — | EP | disclosed |
| US-20040147543-A1 | Aryl substituted imidazoquinolines | 3M INNOVATIVE PROPERTIES COMPANY | 2004-07-29 | — | — | US | disclosed |
| WO-2004058759-A1 | ARYL / HETARYL SUBSTITUTED IMIDAZOQUINOLINES | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2004-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213356-A1 | Nitrogen-Containing Heterocyclyl Substituted Imidazoquinolines and Imidazonaphthyridines | IL2, IFNG, IRF3 | TLR7 58/4885TLR8 136/4885NUDT1 86/4885 |
| US-20160222010-A1 | 4-AMINO-IMIDAZOQUINOLINE COMPOUNDS | TLR4, TLR1, TLR5 | TLR7 4/4885TLR8 9/4885NUDT1 2019/4885 |
| US-20040147543-A1 | Aryl substituted imidazoquinolines | IL2, IFNG, IRF3 | TLR7 68/4885TLR8 220/4885NUDT1 648/4885 |
| US-20150299194-A1 | 4-AMINO-IMIDAZOQUINOLINE COMPOUNDS | TLR4, TLR1, TLR5 | TLR7 4/4885TLR8 9/4885NUDT1 2019/4885 |
| US-20060111387-A1 | ARYL SUBSTITUTED IMIDAZOQUINOLINES | IL2, IFNG, IRF3 | TLR7 68/4885TLR8 220/4885NUDT1 648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.