Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.34 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7706487 | 0.76 | ALDH1A1 (0.60) | ALDH1A1NPC1MEN1KMT2AHPGD | |
| SCHEMBL14433862 | 0.73 | NPC1 (0.47) | PHGDHMGLLALDH1A1NPC1POLB | |
| SCHEMBL11654540 | 0.72 | PHGDH (0.43) | PHGDHMGLLALDH1A1NPC1POLB | |
| SCHEMBL24052080 | 0.71 | PHGDH (0.50) | PHGDHMGLLALDH1A1NPC1POLB | |
| SCHEMBL20233005 | 0.69 | ALDH1A1 (0.50) | ALDH1A1NPC1POLBMEN1KMT2A | |
| SCHEMBL24456618 | 0.69 | ALDH1A1 (0.50) | ALDH1A1NPC1POLBMEN1KMT2A | |
| SCHEMBL1149395 | 0.69 | PHGDH (0.48) | PHGDHMGLLALDH1A1NPC1POLB | |
| SCHEMBL349335 | 0.67 | F2 (0.50) | PHGDHMGLLALDH1A1NPC1POLB | |
| SCHEMBL9061263 | 0.67 | F2 (0.50) | PHGDHMGLLALDH1A1NPC1POLB | |
| SCHEMBL14008731 | 0.67 | PHGDH (0.42) | PHGDHMGLLALDH1A1NPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019118785-A2 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | Praxis Biotech LLC (US) | 2019-06-20 | — | — | WO | disclosed |